| DC21233 |
LJ 001
Featured
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LJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1; specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion; specifically inhibits virus-cell but not cell-cell fusion |
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| DC12172 |
L-JNKI-1 |
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK. |
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| DC21234 |
LKY-047 |
LKY-047 is a decursin derivative that potently and selectively inhibits CYP2J2, competitively inhibits CYP2J2-mediated astemizole O-demethylase and terfenadine hydroxylase activity with Ki of 0.96 and 2.61 uM, respectively. |
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| DC21235 |
LLL3 |
LLL3 is a structural analogue of STA-21 that acts as a novel STAT3 inhibitor, inhibits STAT3-dependent transcriptional and DNA binding activities. |
|
| DC20438 |
LLP2A |
LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM. |
|
| DC21237 |
LLS2 |
LLS2 is a novel potent Galectin-1 (Gal1) inhibitor that decreases membrane-associated H-Ras and K-Ras and contributed to the suppression of pErk pathway. |
|
| DC21238 |
LLS30 |
LLS30 is a potent, allosteric Galectin-1 (Gal-1) inhibitor, inhibits AR negative cells PC3, DU145, and AR positive cells, 22RV1 and CWR-R1 cells with IC50 of 10.4 μM, 5.3 μM, 3.3 μM and 5.9 μM, respectively. |
|
| DC21239 |
LLY-2707 |
LLY-2707 (LLY 2707, LLY2707) is a novel potent, selective, nonsteroidal glucocorticoid receptor antagonist with Ki of 2.13 nM. |
|
| DC21240 |
LLY-283
Featured
|
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM. |
|
| DC10758 |
LM22B-10
Featured
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo. |
|
| DC23127 |
LMD-009 |
LMD-009 (LMD 009, LMD009) is a potent, selective, nonpeptide CCR8 agonist that stimulates CCR8-mediated chemotaxis, inositol phosphate accumulation and calcium release with EC50 of 11-87 nM. |
|
| DC20259 |
LML134
Featured
|
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1]. |
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| DC20275 |
LMP-744 hydrochloride
Featured
|
LMP744(Mj-III-65,NSC-706744) is a DNA intercalator and topoisomerase inhibitor with antitumor activity. |
|
| DC12602 |
LMT-28
Featured
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
|
| DC21247 |
LN-1-255 |
LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor. |
|
| DC25003 |
LOC14
Featured
|
LOC-14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM. |
|
| DC10188 |
Lodoxamide
Featured
|
Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis. |
|
| DC10694 |
Loflucarban
Featured
|
Loflucarban is an antiinfective drug |
|
| DC12324 |
Loganetin |
Loganetin is a non-toxic natural product that may be applied in the antibacterial drug development for treating multidrug-resistant Gram negative infections. |
|
| DC12142 |
LOM612 |
LOM612 is a potent activator of FOXO nuclear translocation, with an EC50 value of 1.5 μM in cells. |
|
| DCAPI1400 |
Lomefloxacin HCl (Maxaquin) |
Lomefloxacin HCl (Maxaquin) |
|
| DC7188 |
Lomeguatrib(PaTrin-2)
Featured
|
Lomeguatrib (PaTrin-2) is a modified guanine base, which can repress the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) with an IC50 value of 6 nM. |
|
| DC9177 |
Lomerizine hydrochloride |
Lomerizine dihydrochloride is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine. |
|
| DC7778 |
Lometrexol(LY 264618)
Featured
|
Lometrexol is a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase (GARFT), was the first GARFT inhibitor to be investigated clinically. |
|
| DC7900 |
AEGR-733(Lomitapide)
Featured
|
Lomitapide (AEGR-733) is a novel proprietary MTP-inhibitor. |
|
| DCAPI1049 |
Lomustine (CeeNU) |
Lomustine (CeeNU) |
|
| DC7455 |
Lonafarnib
Featured
|
Lonafarnib(Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
|
| DCAPI1199 |
Lonidamine
Featured
|
Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis. |
|
| DC9168 |
Loperamide HCl |
Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals. |
|
| DC8907 |
Lopinavir
Featured
|
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM,showed potent activity against COVID-19(SARS-COV-2). |
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