PGN-9856|PGN9856|CAS 863704-91-0|DC Chemicals

Cas No.:	863704-91-0
Chemical Name:	2-(3-(3',4-difluoro-[1,1'-biphenyl]-3-carboxamido)phenoxy)acetic acid
Synonyms:	PGN9856;PGN-9856;PGN 9856
SMILES:	C(O)(=O)COC1=CC=CC(NC(C2C(F)=CC=C(C3=CC=CC(F)=C3)C=2)=O)=C1
Formula:	C₂₁H₁₅F₂NO₄
M.Wt:	383.351
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Coleman RA, et al. Br J Pharmacol. 2018 Oct 20. doi: 10.1111/bph.14525.

Description:

PGN-9856 (PGN9856) is a novel potent, selective prostaglandin EP2 receptor agonist with pKi of > 8.3, shows higi selectivity over EP1 , EP3 , EP4 , DP, FP, IP and TP receptors; displays a potency (pEC50 >8.5) and a maximal response (increase in cAMP) comparable to that of the endogenous agonist PGE2 in cells over-expressing human recombinant EP2 receptors; exhibited tocolytic, anti-inflammatory, and long-acting ocular hypotensive properties consistent with its potent EP2 agonist properties.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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