| DC23973 |
F16
Featured
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A mitochondriotoxic small molecule that selectively inhibits proliferation of mammary epithelial, neu-overexpressing cells, as well as a variety of mouse mammary tumor and human breast cancer cell lines. |
|
| DC23225 |
Dronedarone |
A multichannel blocker agent that has antiarrhythmic activity. |
|
| DC21008 |
Fumonisin B1 |
A mycotoxin produced from F. moniliforme, and an inhibitor of ceramide synthase (sphingosine N-acyltransferase/CerS). |
|
| DC23641 |
AMG 747 |
A nanomolar potent, selective, and orally bioavailable glycine transporter type-1 (GlyT1) inhibitor for the treatment of negative symptoms associated with schizophrenia. |
|
| DC24167 |
Bergaptol |
A natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
|
| DC20476 |
N-palmitoyl-l-leucine |
A natural poduct that functions as a splicing inhibitor with IC50 of 35 uM, blocks a late stage of spliceosome assembly.. |
|
| DC22465 |
Gedunin |
A natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins. |
|
| DC25051 |
Deoxygedunin |
A naturally occurring tetranortriterpenoid that has been found to act as a potent, selective, small-molecule agonist of TrkB with Kd of 1.4 uM. |
|
| DC21030 |
FzM1 |
A negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism. |
|
| DC25093 |
Neuromedin N
Featured
|
A neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.. |
|
| DC22366 |
Bethoxazin |
A new broad spectrum industrial microbicide with applications in material and coating preservation. . |
|
| DC23771 |
HuR inhibitor 5 |
A newly identified, small molecule HuR inhibitor that disrupts HuR multimerization modules and reduces tumor cell survival and proliferation.. |
|
| DC21556 |
RA 839 |
A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling. |
|
| DC25046 |
OSU-2S |
A non-immunosuppressive FTY720 analogue, PKCδ activator with higher antiproliferative potency with IC50 of 2.4, 2.4, and 3.5 uM in Huh7, Hep3B, and PLC5 cells, respectively. |
|
| DC23907 |
Polyoxyethylene 40 stearate
Featured
|
A non-ionic emulsifying agent that can modulate multidrug resistance and enhances antitumor activity of vinblastine sulfate by modulating substrate-stimulated P-gp ATPase activity. |
|
| DC22395 |
NSAH |
A nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM. |
|
| DC22911 |
AH-3960
Featured
|
A non-peptide small molecule agonist of the PTH1 receptor, activates both the cAMP and calcium signaling pathways.. |
|
| DC21236 |
LLL-12 |
A nonpeptide, cell-permeable STAT3 inhibitor that binds directly to the pTyr705 binding site of the STAT3 monomer. |
|
| DC24049 |
Anamorelin fumarate
Featured
|
A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC24050 |
Anamorelin hydrochloride
Featured
|
A non-peptide, centrally-penetrant and selective agonist of GHSR with appetite-enhancing and anabolic effects. |
|
| DC22428 |
Ro 64-6198 hydrochloride |
A nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41. |
|
| DC23006 |
XIB-4035 |
A nonpeptidyl small molecule agonist of GDNF family receptor α1 (GFRα-1). |
|
| DC22611 |
N6-[2-(4-Aminophenyl)ethyl]adenosine |
A non-selective agonist of Adenosine A3 receptor. |
|
| DC22619 |
Rotigotine
Featured
|
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM). |
|
| DC22609 |
rac-Rotigotine hydrochloride |
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM). |
|
| DC22662 |
Carteolol |
A non-selective beta blocker used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.. |
|
| DC23203 |
E4CPG
Featured
|
A non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.. |
|
| DC24159 |
(R)-Flurbiprofen |
A non-steroidal anti-inflammatory drug (NSAID). |
|
| DC22769 |
Droloxifene |
A nonsteroidal selective estrogen receptor modulator (SERM) that shows 10- to 60-fold increased affinity for the estrogen receptor compared with Tamoxifen. |
|
| DC21706 |
STX3451 |
A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM. |
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