| DC21281 |
ADU-S100
Featured
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ADU-S100 (MIW815) is a synthetic cyclic dinucleotide agonist of STING, elicits potent and durable anti-tumor immunity when administered IT in pre-clinical syngeneic tumor models.. |
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| DC11097 |
ADX-102 (Reproxalap;NS-2)
Featured
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ADX-102 (Reproxalap, NS-2) is a novel small molecule immunomodulator that covalently binds aldehydes including malondialdehyde and 4-hydroxynonenal, which have been shown to mediate inflammatory pain; DX-102 is a promising agent for the treatment of dry eye disease. |
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| DC7703 |
AEBSF-hydrochloride
Featured
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AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor. |
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| DC21988 |
AER-271
Featured
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AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility. |
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| DC21989 |
AES-135
Featured
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AES-135 (AES135) is a novel HDAC inhibitor that biochemically inhibits HDACs 3, 6, 8 and 11 with IC50 values of 190-1100 nM. |
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| DC8355 |
Adjudin (AF-2364)
Featured
|
AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague–Dawley rats. |
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| DC23140 |
AF38469
Featured
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AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin |
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| DC12539 |
AF40431 |
AF40431 (AF-40431) is the first reported small-molecule ligand of the VPS10P family sorting receptor Sortilin with IC50 of 4.4 uM, binds in the neurotensin-binding site of sortilin.. |
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| DC11170 |
AF64394
Featured
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AF64394 is a potent, selective GPR3 inverse agonist with pIC50 of 7.3, displays >100-fold selectivity over GPR6 and GPR12. |
|
| DC23642 |
AF-792 |
AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors. |
|
| DC20108 |
Afegostat D-Tartrate (D-Isofagomine (D-Tartrate); Isofagomine (D-Tartrate)) |
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity. |
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| DC10844 |
Aftin-4
Featured
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Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. |
|
| DC8507 |
AG13958 |
AG13958 is a VEGF inhibitor that was clinical development by Pfizer in 2006-07 for treatment of age-related macular degeneration (AMD). |
|
| DC1078 |
AG-1478 (Tyrphostin AG-1478)
Featured
|
AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM. |
|
| DC7051 |
AG-18
Featured
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AG-18(RG-50810; Tyrphostin A23) inhibits EGFR with IC50 of 40 μM. |
|
| DC12499 |
AG-270
Featured
|
AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC50 of 14 nM. |
|
| DC10623 |
AG-494
Featured
|
AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 µM in HT-22 cells. |
|
| DC12196 |
Aganepag (AGN 210937) |
Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM, and shows no activity at EP4 receptor. Aganepag can be used in the research of wound healing, scar reduction, scar prevention and wrinkle treatment and prevention. |
|
| DC21990 |
AGI-14100 |
AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor. |
|
| DC12225 |
AGL-2263 |
AGL-2263 is an insulin receptor (IR) blocker. |
|
| DC7767 |
AGN 194310 |
AGN 194310(VTP-194310) is a potent and selective pan-RARs agonist with Kd values of 3/2/5 nM for RARα/β/γ respectively. |
|
| DC20304 |
AGPS-IN-1a |
AGPS-IN-1a is a potent inhibitor of the ether lipid-generating enzyme alkyl-glycerone phosphate synthase (AGPS), selectively lowers ether lipid levels in several types of human cancer cells and impairs their cellular survival and migration.. |
|
| DC12535 |
AgrA inhibitor F19 |
AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription. |
|
| DC7632 |
AHAS inhibitor(BTB06584)
Featured
|
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). |
|
| DC8735 |
AHU-377 hemicalcium salt
Featured
|
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
|
| DC8734 |
AHU-377(Sacubitril) |
AHU-377 is an inhibitor of neprilysin with IC50 value of 5 nM. |
|
| DC20305 |
AI-10-104
Featured
|
AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays. |
|
| DC9402 |
Letermovir(AIC-246)
Featured
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AIC246 is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. |
|
| DC23900 |
AICAR phosphate
Featured
|
AICAR phosphate (Acadesine, AICA Riboside, NSC 105823) is a selective AMPK activator in both hepatocytes and adipocytes. |
|
| DC12402 |
AJM300 |
AJM300 (AJM 300, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis.. |
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