| DC20795 |
BIO 8898 |
BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM. |
|
| DC11069 |
BIO124 |
BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1.. |
|
| DC12401 |
BIO922 |
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors. |
|
| DC8368 |
BIO-acetoxime
Featured
|
BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO |
|
| DC20320 |
Bio-AMS |
Bio-AMS is a chemical inhibitor of Mycobacterium tuberculosis biotin protein ligase ( MtBPL) with Kd of 0.865 nM. |
|
| DC23078 |
Biperiden
Featured
|
Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
|
| DC25079 |
Biperiden hydrochloride
Featured
|
Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
|
| DC5023 |
Birinapant (TL32711)
Featured
|
Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. |
|
| DC10863 |
Bis(tributylammonium) difluoromethylenediphosphonate
Featured
|
Bis(tributylammonium) difluoromethylenediphosphonate |
|
| DC10504 |
BISF-3
Featured
|
BISF CAS 118511-97-0 |
|
| DC20798 |
Bisperoxovanadium |
Bisperoxovanadium (bpV(phen) potassium hydrate) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 =38 nM), also inhibits the vascular endothelial PTP, PTP-β (IC50=3 |
|
| DC20212 |
Bisphenol A |
Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties. |
|
| DC21599 |
Bis-T-23 |
Bis-T-23 is a small molecule that stimulates actin-dependent dynamin oligomerization and promotes dynamin GTPase activity, increases actin polymerization in injured podocytes. |
|
| DC11307 |
Bitertanol |
Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including V. inaequalis and V. pirina. |
|
| DC9616 |
BIX 02565
Featured
|
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.
|
|
| DC23383 |
Bizine |
Bizine is a phenelzine analog that inhibits LSD1 with Ki of 59 nM, displays 23-fold, 63-fold, and >100-fold selectivity for LSD-1 over MAOA, MAOB, and LSD2 respectively. |
|
| DC20739 |
BJE6-106 |
BJE6-106 (B106) is a potent, selective PKCδ inhibitor with IC50 of 50 nM, displays excellent selectivity over classical PKC isozymes (a 1,000-fold PKCδ selectivity over PKCα). |
|
| DC22637 |
BKI1369
Featured
|
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves. |
|
| DC23439 |
BL-1020 |
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist. |
|
| DC20800 |
BL-918
Featured
|
BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells. |
|
| DC12391 |
BL-AD008
Featured
|
BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK; demonstrates remarkable anti-proliferative activities toward cervical cancer cells and could induce apoptosis by death-receptor and mitochondrial pathways; also sho |
|
| DC20107 |
Blasticidin S hydrochloride |
Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes. Blasticidin S is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. |
|
| DC20801 |
BLT-1
Featured
|
BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages. |
|
| DC12650 |
BLU-667 trans form |
BLU-667 trans form is the trans form of BLU-667, which is a highly potent, selective, next generation RET inhibitor.. |
|
| DC11152 |
BLU-782
Featured
|
BLU-782 (BLU782) is a novel potent, selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 Nm. |
|
| DC23305 |
BM-1197 |
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1. |
|
| DC20802 |
BM-635 |
BM-635 is a small molecule anti-mycobacterial compound acting by inhibiting the mycobacterial membrane protein Large 3 (MmpL3). |
|
| DC23304 |
BM-957 |
BM-957 is a highly potent, dual Bcl-2 and Bcl-xL inhibitor with Ki of <1 nM for both, IC50 of 5.4 and 6.0 nM, respectively. |
|
| DC8270 |
BML-277
Featured
|
BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM. |
|
| DC20321 |
Bm-MPK1-IN-15b |
Bm-MPK1-IN-15b is a potent, orally bioavailable inhibitor of B. malayi stress-activated kinase Bm-MPK1 with IC50 of 24 nM. |
|
