| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC74159 | SACLAC | SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines. |
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| DC74160 | SAN4825 | SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM. |
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| DC74161 | SAR439883 Featured | SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively. |
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| DC74162 | SB1501 | SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo. |
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| DC74163 | SBI-0802936 | SBI-0802936 (SBI 0802936) is an analog of SMIP004-7, inhibits NADH:ubiquinone oxidoreductase (complex I), 4-6 times more potently than SMIP004-7, acting in the same uncompetitive fashion as SMIP004-7. |
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| DC74164 | SBL-105 | SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH). |
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| DC74166 | SB-U015 | SB-U015 is a MitoQ derivative and tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor. |
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| DC74167 | SC-919 | SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively. |
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| DC74168 | Secdin | Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM. |
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| DC74169 | Seletracetam | Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy. |
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| DC74170 | SFI003 | SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM. |
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| DC74171 | SHR170008 | SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme. |
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| DC74172 | SI-2 hydrochloride | A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2. |
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| DC74173 | Siastatin B | Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases. |
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| DC74174 | SJ572946 | SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays. |
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| DC74175 | SMC-21598 | SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3. |
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| DC74176 | SMIP004-7 | SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I). |
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| DC74177 | SN34960 Featured | SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
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| DC74178 | SP-8008 | SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation. |
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| DC74179 | SPI-0324 | SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt. |
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| DC74180 | SPI-1477 | SPI-1477 (SPI-77) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.1 nM, without affecting WT Htt. |
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| DC74181 | SPI-21 | SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM. |
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| DC74182 | SpiD7 | SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells. |
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| DC74183 | SR-9011 hydrochloride | A potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively. |
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| DC74184 | SRP-001 | SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP. |
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| DC74185 | SS-1-148 Featured | SS-1-148 is a potent, selective inhibitor of human ornithine δ-aminotransferase (hOAT) with Ki of 60 uM, shows excellent selectivity over other related aminotransferases (e.g., GABA-AT). |
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| DC74186 | SST0871AA1 | SST0871AA1 is a small molecule Heparanase (Hpse) inhibitor with IC50 of 0.64 uM. |
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| DC74187 | SST0872AA1 | SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM. |
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| DC74188 | STF-1084 | STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM. |
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| DC74189 | STOCK1S-14279 | STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1. |
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