| DC74545 |
MBZM-N-IBT |
MBZM-N-IBT is a small molecule inhibitor of Chikungunya virus (CHIKV), inhibits CHIKV infection in vitro in RAW 264.7 cells with IC50 of 22.34 uM, targets CHIKV nsP2 protease activity. |
|
| DC74546 |
SBI-0090799 |
SBI-0090799 (SBI 0090799) is a selective and potent inhibitor of Zika virus (ZIKV) replication, inhibits replication of multiple ZIKV strains and in different cell systems. |
|
| DC74547 |
UMM-766 |
UMM-766 is an orally available nucleoside analog with potent, broad-spectrum antiviral activity against multiple members of orthopoxviruses (EC50<1 uM against VACV). |
|
| DC74548 |
USC-373 |
USC-373 is a phosphonate prodrug of HPMPC (cidofovir) with activity against VZV and other DNA viruses. |
|
| DC74549 |
EOS789 |
EOS789 is a potent, pan-phosphate transporter inhibitor, inhibits phosphate uptake in a noncompetitive manner for human NaPi-IIb, PiT-1, and PiT-2 with IC50 of 6.8, 1.5 and 1.7 uM, respectively. |
|
| DC74550 |
EOS789 tosylate |
EOS789 tosylate is a potent, pan-phosphate transporter (NaPi-2b, PiT-1, PiT-2) inhibitor, inhibits phosphate uptake in a noncompetitive manner for human NaPi-IIb, PiT-1, and PiT-2 with IC50 of 6.8, 1.5 and 1.7 uM, respectively. |
|
| DC74551 |
LY3358966 |
LY3358966 is a potent, selective inhibitor of the intestinal sodium-dependent phosphate cotransporter NPT2b (NaPi-2b, SLC34A2), inhibits phosphate uptake in human NPT2b expressed in CHO cells with IC50 of 32.4 nM. |
|
| DC74552 |
TY-2136 |
TY-2136 is a next generation ROS1/TRK/ALK inhibitor with IC50 of 1.6 nM and 460.1 nM for ROS1 G2032R and TRKA G595R, respectively, inhibits ROS1/TRK/ALK mutations and overcomes drug resistance due to acquired solvent-front mutations. |
|
| DC74553 |
1D-142 |
1D-142 is a novel small molecule RHO family of GTPase RAC1 inhibitor, inhibits Rac1-GEF interaction and reduces Rac1-mediated TNFα-induced NF-κB nuclear translocation during cell proliferation and migration. |
|
| DC74554 |
CS7171 |
CS7171 is an effective, blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
|
| DC74555 |
GYS32661
Featured
|
GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays. |
|
| DC74556 |
JKF-034 |
JKF-034 is an effective,blood-brain barrier (BBB) permeable small molecule inhibitor of hippocampal Rac1 activity, rescues learning deficits in APP/PS1 mice. |
|
| DC74557 |
PREX-in1
Featured
|
PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain. |
|
| DC74558 |
BAY 2686013 |
BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively. |
|
| DC74559 |
PA-915 |
PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM. |
|
| DC74560 |
Ro 25-1553 |
Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM. |
|
| DC74229 |
Zenuzolac |
Zenuzolac (GLS1027, VGX-1027) is a small molecule immunosuppressant and an orally available isoxazole compound, inhibits toll-like receptor 4 (TLR4) activity, has shown promise for the treatment of several neuroinflammatory disorders. |
|
| DC74243 |
VPC-80051 |
VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1. |
|
| DC74573 |
T1-44 |
T1-44 is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It exhibits anti-tumor activity in pancreatic cancers. |
|
| DC74575 |
MSU-42011 |
MSU-42011 is an orally active agonist of retinoid X receptor (RXR). MSU-42011 inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. MSU-42011 can be used for cancer research. |
|
| DC74576 |
Fluorofurimazine
Featured
|
Fluorofurimazine is a novel furimazine analogue, with increased aqueous solubility enabling higher signal emission than furimazine for bioluminescence imaging. Fluorofurimazine enables higher substrate loading and improved optical imaging sensitivity in in-vivo. |
|
| DC74577 |
L-Cysteine (hydrochloride hydrate) |
L-Cysteine hydrochloride hydrate is an essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione, and taurine. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans. |
|
| DC74578 |
L-Cystine (dihydrochloride) |
L-Cystine dihydrochloride is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies and as a sulfur-containing precursor of glutathione (GSH) synthesis. L-Cystine dihydrochloride homeostasis is also important for GSH functions. |
|
| DC74579 |
NADP sodium salt |
NADP sodium salt, a nicotinamide adenine dinucleotide, is a coenzyme that plays a vital role in various metabolic reactions within living cells. NADP sodium salt is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP+) and reduced (NADPH). |
|
| DC74580 |
Sodium alginate |
Sodium alginate is a sodium salt of alginic acid, can be extracted and purified from the cell walls brown seaweed Laminaria japonica. It has chelating activity and can be used to adsorb heavy metal ions, also has mucosal-protective and hemostatic effects and used in food additives and pharmaceuticals. |
|
| DC74581 |
Sodium Montmorillonite |
Sodium Montmorillonite is a layered clay mineral (2:1 phyllosilicate) that belongs to a class of the smectite group. It can be used for preparation of new drug delivery systems, especially for slow release of protonable drugs due to its high degree of surface area and high capacity for cation exchange. |
|
| DC74582 |
ALKBH5 inhibitor 2 (Cpd 20m) |
ALKBH5 inhibitor (Cpd 20m) is a potent and selective inhibitor of RNA m6A demethylase AlkB homolog 5 ALKBH5 with IC50 of 21 nM. |
|
| DC74583 |
ZK53
Featured
|
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP). It exhibits an EC50 of 1.37 μM for α-casein hydrolysis by HsClpP. ZK53 treatment allosterically activates HsClpP to uncontrollably degrade the essential mitochondrial proteins and is inactive toward bacterial ClpP proteins. |
|
| DC74586 |
Pyrimidine |
Pyrimidine is an endogenous metabolite. It is used to study the photoinduced ion chemistry of the halogenated pyrimidines, a class of prototype radiosensitizing molecules, and is also used to assess pyrimidine/purine asymmetry quantitatively. |
|
| DC74588 |
FL118 |
FL118(10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin analog, is a potent and orally active inhibitor of Survivin. FL118 also selectively and independently inhibits three additional cancer-associated survival genes Mcl-1, XIAP, and cIAP2 in a p53 status-independent manner. FL118 displays potent antitumor activity and can be used in cancer research. |
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