| DC8465 |
Apatinib (free base)
Featured
|
Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. |
|
| DC20310 |
Apcin
Featured
|
Apcin is a cell-permeable, small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor, which binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates. |
|
| DC8804 |
APD597(JNJ-38431055)
Featured
|
APD597(JNJ-38431055) is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119. |
|
| DC22430 |
APD916 |
APD916 is a potent and selective antagonist of the H3 receptor with Ki of 0.7 nM for rH3R. |
|
| DC11077 |
Azelaprag |
apelin receptor. |
|
| DC21448 |
Apicidin
Featured
|
Apicidin (OSI 2040) is a fungal metabolite that exhibits potent, broad spectrum antiprotozoal activity in vitro, potently inhibits HDAC with IC50 of 0.7 nM in an enzyme activity assay. |
|
| DC8276 |
Apilimod mesylate
Featured
|
Apilimod(STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, IL-12 production in cultures of IFN-r/LPS–stimulated human PBMCs is strongly inhibited by STA-5326 with an IC50 of 10 nM. |
|
| DC23406 |
Aplaviroc |
Aplaviroc (GSK-873140. |
|
| DC23522 |
Aplaviroc HCl
Featured
|
Aplaviroc, also known as AK-602; GW-873140; GW873140A; ONO-4128, is a CCR5 entry inhibitor for the potential treatment of HIV infection. Aplaviroc (GW873140) binds specifically to human cellular CC chemokine receptor 5 (CCR5) and demonstrates potent anti-human immunodeficiency virus activity in vitro in the subnanomolar range. In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5. |
|
| DC25100 |
Apogossypol |
Apogossypol (NSC 736630) is a Bcl-2 family antagonist that binds to Bcl-XL, Bcl-2 and Bcl-xL with IC50 of 2.6, 2.8 and 3.69 uM, respectively. |
|
| DC23901 |
R-(-)-Apomorphine
Featured
|
Apomorphine hydrochloride hemihydrate is a non-selective dopamine agonist which activates both D1-likeand D2-like receptors, with some preference for the latter subtypes.. |
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|
| DC10122 |
Apoptozole
Featured
|
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
|
| DC7003 |
Apricitabine |
Apricitabine is a novel nucleoside reverse transcriptase inhibitor for the treatment of HIV infection that is refractory to existing drugs |
|
| DC10207 |
Aprotinin |
Aprotinin is a serine protease inhibitor isolated from bovine lung which inhibits trypsin and chymotrypsin with Ki values of 0.06 pM and 9 nM, respectively. |
|
| DC9809 |
APS-3-77 HCl
Featured
|
APS-3-77 is the negative binder of KSR2. |
|
| DC21999 |
APTO-253 hydrochloride |
APTO-253 is a small molecule inducer of KLF4, stabilizes G-quadruplex DNA and reduces MYC mRNA expression and protein levels. |
|
| DC20672 |
APX001A
Featured
|
APX001 (APX 001A;E1210) is a novel broad-spectrum antifungal agent that inhibits the fungal protein Gwt1, demonstrates significantly acitive MIC50 and MIC90 values of 0.004 and 0.031 ug/ml (16 strains of C. auris). |
|
| DC11194 |
APX2009 |
APX2009 (APX-2009) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.45 uM for redox EMSA inhibition. |
|
| DC11195 |
APX2014 |
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
|
| DC23311 |
AQ-101 |
AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53. |
|
| DC12155 |
AQ-13 dihydrochloride |
AQ-13 dihydrochloride is an aminoquinoline antimalarial drug that is effective against chloroquine-resistant strains of Plasmodium falciparum. |
|
| DC20673 |
AQW-051 |
AQW-051 is a novel, potent and selective, orally bioavailable, brain-penetrant α7 nAChR partial agonist with pKd of 7.56. |
|
| DC23139 |
AQX 1125 |
AQX 1125 (Rosiptor) is a specific, orally bioavailable SHIP1 activator. |
|
| DC20674 |
AR03 |
AR03 (AR-03, AR 03, Ape1 repair inhibitor 03) is a novel small molecule inhibitor of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) endonuclease activity with IC50 of 5 uM. |
|
| DC8764 |
AR 231453
Featured
|
AR231453 is a potent and selective small molecule agonist of GPR119 that enhances glucose-dependent insulin secretion and glucagon-like peptide 1 (GLP-1) release; Antidiabetic agent. |
|
| DC22493 |
ARA-290(Cibinetide)
Featured
|
ARA-290 (Cibinetide) is a non-erythropoietic erythropoietin (EPO) derivative. |
|
| DC8888 |
Ara-G
Featured
|
Ara-G (9-β-D-Arabinofuranosyl guanine) is an inducer of apoptosis, inhibitor of DNA synthesis, an antimetabolite, and antineoplastic. |
|
| DC10862 |
Aramchol |
Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. |
|
| DCAPI1051 |
Arbidol HCl (Umifenovir)
Featured
|
Umifenovir is currently being investigated as a potential treatment and prophylactic agent for COVID-19 caused by SARS-CoV2 infections in combination with both currently available and investigational HIV therapies. Arbidol hydrochloride (Umifenovir hydroc |
|
| DC20675 |
AR-C102222 |
AR-C102222 is a potent, selective iNOS inhibitor with IC50 of 35 nM, dislapys 3,000-fold and 20-fold selectivity over eNOS and nNOS respectively. |
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