Cat. No. | Product name | CAS No. |
DC24158 |
Rofecoxib
A potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells. |
162011-90-7 |
DC20810 |
Pexacerfont
A potent, selective and orally active CRF1 receptor antagonist with IC50 of 6.1 nM, >1,000-fold selectivity over CRF-binding protein and biogenic amine receptors. |
459856-18-9 |
DC20923 |
CP 376395 hydrochloride
A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM). |
1013933-37-3 |
DC20689 |
ASB 14780
A potent, selective and orally active cytosolic phospholipase A2α (cPLA2α) inhibitor with IC50 of 20 nM. |
1069046-00-9 |
DC21689 |
SR 142948A
Featured
A potent, selective and orally active neurotensin receptor antagonist with IC50 of 1.19 nM. |
184162-21-8 |
DC23621 |
YM543
A potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1. |
1174340-24-9 |
DC21842 |
Darexaban
A potent, selective and orally available factor Xa (FXa) inhibitor with IC50 of 54.6 nM. |
365462-23-3 |
DC21718 |
T-3364366
A potent, selective and orally available inhibitor of delta-5 desaturase (D5D) with Ki of <2.7 nM and IC50 of 19 nM, with excellent selectivity over D6D and SCD. |
1356354-09-0 |
DC20768 |
Tonapofylline
A potent, selective and orally bioavailable adenosine A1 (A1A) receptor antagonist with Ki of 7 nM. |
340021-17-2 |
DC22682 |
INCB9471
A potent, selective and orally bioavailable CCR5 antagonist IC50 of 6.5 nM, Kd of 3.1 nM in human PBMCs. |
869769-98-2 |
DC23643 |
JNJ 54166060
A potent, selective and orally bioavailable P2X7 receptor with IC50 of 4 nM and 115 nM for hP2X7 and rP2X7, respectively. |
1627900-41-7 |
DC21600 |
S1P Lyase inhibitor 31
A potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM. |
1538574-95-6 |
DC23207 |
JNJ-17203212
Featured
A potent, selective and orally bioavailable TRPV1 receptor antagonist with IC50 of 65 nM and 102 nM for hTRPV1 and rTRPV1, respectively. |
821768-06-3 |
DC21464 |
Eribaxaban
A potent, selective and orally efficacious factor Xa (FXa) inhibitor with IC50 of 0.32 nM. |
536748-46-6 |
DC25047 |
Calphostin C
A potent, selective and photo-dependent inhibitor of PKC with IC50 of 50 nM. |
121263-19-2 |
DC20602 |
5F 203
Featured
A potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway. |
260443-89-8 |
DC21576 |
RO-5508887
A potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin. |
1310347-50-2 |
DC21103 |
GW405833 hydrochloride
A potent, selective cannabinoid receptor CB2 agonist with Ki of 3.6 nM, 1200-fold selectivity over CB1. |
1202865-22-2 |
DC20658 |
AM1241
Featured
A potent, selective cannabinoid receptor CB2 agonist with Ki of 7.1 nM, >80-fold selectivity over CB1 receptors in radioligand binding assay. |
444912-48-5 |
DC21376 |
NESS-0327
A potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM, >60,000-fold selective for the CB1 receptor versus CB2 receptor (Ki=21 nM). |
494844-07-4 |
DC23357 |
CBP bromodomain inhibitor
a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family.. |
2161356-61-0 |
DC22697 |
PF-04756956
A potent, selective CCK1 receptor agonist with EC50 of 0.47 nM. |
1228934-52-8 |