| DC22995 |
IRES-J007
Featured
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IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242. |
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| DC22542 |
Roflumilast Impurity E |
An impurity of Roflumilast, which is a selective and long-acting inhibitor of PDE-4 with IC50 value of 0.8 nM.. |
|
| DC20988 |
Indirubin E804 |
An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro. |
|
| DC22998 |
MIND4-17 |
An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM. |
|
| DC23993 |
Aldose reductase-IN-1 |
An inhibitor of aldose reductase with IC50 of 28.9 pM. |
|
| DC22549 |
KDM5A-IN-1 |
An inhibitor of histone demethylase.. |
|
| DC23937 |
SIBA |
An inhibitor of the IMP-selective cytosolic 5'-nucleotidase (IC50=2-6 mM). |
|
| DC22360 |
Valifenalate |
An insecticide agent that is approved for application on high-value crops such as grapes, tomatoes and other vegetables.. |
|
| DC24195 |
Benoxafos |
An insecticide agent.. |
|
| DC24177 |
Mitiglinide calcium hydrate
Featured
|
An insulin secretion stimulator by closing the ATP-sensitive potassium KATP channels in pancreatic β cells. |
|
| DC24164 |
Proparacaine hydrochloride |
An irreversible local anesthetic. |
|
| DC22612 |
Afatinib
Featured
|
An irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
|
| DC11640 |
PK-11195
Featured
|
PK 11195 is a ligand of translocator protein. It targets Leishmania chemotherapy (IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively). |
|
| DC22576 |
MSI-1436 |
An non-competitive, allosteric inhibitor of PTP1B with Ki of 0.6 uM for PTP1B1-405. |
|
| DC11911 |
Rovazolac
Featured
|
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1. |
|
| DC22997 |
BI-653048 |
An oral glucocorticoid agonist for the treatment of rheumatoid arthritis.. |
|
| DC24069 |
CI-947
Featured
|
An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.. |
|
| DC23721 |
Metribolone |
An orally active anabolic-androgenic steroid and a 19-nortestosterone derivative that has been widely used in scientific research as a hot ligand in androgen receptor (AR) ligand binding assays (LBAs) and as a photoaffinity label for the AR.. |
|
| DC11934 |
LQB-118 |
An orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo. |
|
| DC24141 |
Lexibulin dihydrochloride |
An orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo. |
|
| DC23019 |
PACMA 31
Featured
|
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI. |
|
| DC22713 |
L-733060 |
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
|
| DC22690 |
L-733060 hydrochloride |
An orally active, non-peptide, selective antagonist for the NK1 receptor with Ki of 0.8 nM. |
|
| DC21705 |
STX-213 |
An orally active, second-generation steroid sulfatase inhibitor with IC50 of 0.5 nM. |
|
| DC22943 |
Laniquidar |
An orally active, third-generation P-glycoprotein inhibitor that inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycopro |
|
| DC22793 |
PF 04942847 |
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM. |
|
| DC21242 |
LM11A-31 dihydrochloride
Featured
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
|
| DC20609 |
Elobixibat |
An orally available, potent and selective ileal bile acid transporter (IBAT) inhibitor for the treatment of constipation.. |
|
| DC23854 |
Vorolanib |
An orally available, small molecule dual VEGFR/PDGFR kinase inhibitor with antiangiogenic and antineoplastic activities. |
|
| DC23240 |
Athidathion |
An organophosphate insecticide agent.. |
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