| Cat. No. | Product Name | Field of Application | Chemical Structure |
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| DC60573 | VVD-214 (RO7589831) Featured | VVD-214 (RO7589831) is a synthetic lethal allosteric inhibitor of WRN helicase. VD-214 covalently engages cysteine 727 of WRN in a nucleotide cooperative manner and inhibits ATP hydrolysis and helicase activity, resulting in widespread double-stranded DNA breaks, nuclear swelling, and cell death in MSI-high, but not microsatellite stable cells. |
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| DC60574 | RMC-6236 Featured | RMC-6236 is a first-in-class, potent, oral tri-complex RASMULTI(ON) small molecule inhibitor designed to treat cancers driven by a variety of RAS mutations. |
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| DC60575 | U-101 Featured | U-101 is an ionizable lipid for mRNA delivery. U-101-LNP/IL-2F mRNA formulation demonstrats effective antitumor activity and safety.LNPs containing lipid U-101 and encapsulating mRNA encoding a fusion protein composed of IL-2, a linker, and CD25 inhibit tumor growth in an MC-38 mouse xenograft model. |
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| DC60576 | AZD8421 Featured | AZD8421 is a highly selective CDK2 inhibitor with IC50 of 9 nM and shows selectivity over CDK1, CDK4 and CDK6. AZD8421 shows robust monotherapy activity in a CCNE1 amplified ovarian model OVCAR3 with regressions seen with monotherapy and in combination with palbociclib. |
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| DC65967 | DBCO-PEG4-acid Featured | DBCO-PEG4-acid is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates. |
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| DC60577 | HC-7366 Featured | HC-7366 is an orally bioavailable and efficacious GCN2 (general control nonderepressible 2) kinase activator with IC50 of 12 nM. |
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| DC65968 | Bz-(Me)Tz-NHS Featured | Bz-(Me)Tz-NHS is a click chemistry reagent containing an methyltetrazine group. Bz-(Me)Tz-NHS is 3rd generation Click-Linker for Cu-free click conjugation. |
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| DC60579 | Lipid B3 Featured | Lipid B3 is a biodegradable ionizable lipid for liver targeted delivery. Lipid B3-LNP shows high delivery efficacy and low toxicity in delivering RNA to liver cells. |
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| DC65969 | SUN 75856 Featured | SUN 75856, also known as N-trifluoroacetyl (TFA) protected aminolink C6 phosphoramidite for the synthesis of 5'-amino-modified oligonucleotides. TFA protection is smoothly removed during ammonia deprotection, and does not require any additional steps. If necessary, the resulting oligonucleotides can be purified by ion exchange chromatography, or gel electrophoresis. This product has no formal name at the moment. |
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| DC60580 | Endosidin5(ES5) Featured | Endosidine 5 (ES5), is one of the most potent small molecules interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm. The delivered mRNAs is greatly enhanced via inhibition of endocytic recycling in cells and in live mice. NAV2729 (NAV) and endosidin 5 (ES5), resulted in significant enhancement (1.5–2 folds) of LNP-mediated delivery of Fluc mRNAs. Incubation of NAV and ES5 together caused modest further increases in Fluc expression in comparison to the sole application of either compound. |
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| DC65971 | (S)-5-(3-(heptyloxy)-5-(octan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65972 | (R)-5-(3-(heptyloxy)-5-(octan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65973 | 5-(3-((R)-octan-2-yloxy)-5-((S)-octan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65974 | 5-(3,5-bis((S)-octan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65975 | 5-(3,5-bis((R)-octan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65976 | 5-(3-(heptan-2-yloxy)-5-(hexyloxy)benzyloxy)isophthalic acid Featured |
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| DC65977 | 5-(3,5-bis(heptan-2-yloxy)benzyloxy)isophthalic acid Featured |
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| DC65978 | 1-[1-Phenyl-3,4-dihydro-1h-pyrido[3,4-b]indol-2(9h)-yl]pentan-1-one Featured |
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| DC65979 | HT-2157 Featured |
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| DC65980 | NSC 102533 Featured | NSC 102533 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent. |
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| DC65981 | (S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid Featured |
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| DC65982 | 10-METHYL-9-(PHENOXYCARBONYL)ACRIDINIUM FLUOROSULFONATE Featured | 10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate, a phenyl ester of acridinium esters, is a fluorescent dye that produces chemiluminescent under neutral conditions. 10-Methyl-9-(phenoxycarbonyl)acridinium fluorosulfonate can be used for the measurement of hydrogen peroxide. |
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| DC65983 | 10-Methyl-9-(phenoxycarbonyl) Acridinium (trifluoromethylsulfonate) Featured |
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| DC65984 | Indole-3-acetyl-L-tryptophan Featured |
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| DC65985 | 4H-Thiopyran-4-one, 2,6-di-2-thienyl Featured |
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| DC65986 | Butyl isobutyl phthalate Featured | Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment. |
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| DC65987 | (S)-2-amino-N1-benzhydrylpentanediamide Featured |
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| DC65988 | AB 17655 Featured |
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| DC65989 | 2-(12,14-Dioxo-11,12,14,15-tetrahydro-9H-9,10-[3,4]epipyrroloanthracen-13(10H)-yl)hexanoic acid Featured |
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| DC65990 | Desmethylcarfentanil acid Featured |
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