A104 |
Bemarituzumab Biosimilar(Anti-FGFR2 / CD332 Reference Antibody)
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Bemarituzumab is a first-in-class, humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has the potential for cancer research. |
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A105 |
Vofatamab Biosimilar(Anti-FGFR3 / CD333 Reference Antibody )
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Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). |
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A106 |
U3-1784 Biosimilar(Anti-FGFR4 / CD334 Reference Antibody)
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A107 |
Radretumab Biosimilar(Anti-Fibronectin Reference Antibody)
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DC66691 |
L19TNF
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A109 |
Rosopatamab Biosimilar(Anti-FOLH1 / PSMA Reference Antibody)
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Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 (177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency. |
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A110 |
Pelgifatamab Biosimilar(Anti-FOLH1 / PSMA Reference Antibody)
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Pelgifatamab (BAY-2315497) is a prostate-specific membrane antigen (PSMA) antibody. Pelgifatamab can be covalently linked to a binding moiety of 225Ac and used for metastatic castration-resistant prostate cancer (mCRPC) research. |
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A111 |
Mirvetuximab Biosimilar(Anti-FOLR1 / FRA Reference Antibody)
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Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research. |
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DC66695 |
Cofrogliptin
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Cofrogliptin (HSK7653) (compound 2), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with Long-acting antidiabetic efficacy. Cofrogliptin (compound 2) has a great potential for type 2 diabetes mellitus (T2DM) . |
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DC66696 |
(R)-2-Thioxothiazolidine-4-carboxylic acid-13C3
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(R)-2-Thioxothiazolidine-4-carboxylic acid-13C3 is the 13C-labeled (R)-2-Thioxothiazolidine-4-carboxylic acid. Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified. |
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DC66697 |
2-Thioxothiazolidine-4-carboxylic Acid
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DC66698 |
STING agonist-12
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STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. |
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A619 |
Sacituzumab govitecan
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Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity. |
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DC66700 |
(S,R)-LSN3318839
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(S,R)-LSN3318839 is the stereoisomer of LSN3318839 (HY-142162). LSN3318839 is an orally active positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). |
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DC66701 |
(3R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)pyrrolidin-3-ol
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A112 |
Farletuzumab Biosimilar(Anti-FOLR1 / FRA Reference Antibody)
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Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer. |
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A114 |
Dompe patent anti-FOLR1 Biosimilar(Anti-FOLR1 / FRA Reference Antibody)
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A116 |
BMS-986012 Biosimilar(Anti-Fucosyl GM1 Reference Antibody)
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A130 |
Vantictumab Biosimilar(Anti-FZD Reference Antibody)
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Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab is being studied against cancers such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma. |
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A131 |
U.Toronto patent anti-FZD7 Biosimilar(Anti-FZD7 Reference Antibody)
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DC60641 |
CD-005
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CD-005 is a low-molecular-weight gelator that can be used to prepare gels for proteins and vaccines. CD-005 can physically entrap proteins, preventing their irreversible aggregation, and maintain protein function for at least 4 weeks even at temperatures up to 50°C. |
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DC66707 |
Casdatifan
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Casdatifanum is a hypoxia-inducible factor (HIF) inhibitor. |
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DC66708 |
BMS-986408
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BMS-986408 is a DGK inhibitor. |
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DC66709 |
BAY-2925976
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BAY-2925976 is an ARα2C antagonist. |
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DC66710 |
AZD4144
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AZD4144 is an NLRP3 inhibitor. |
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DC66711 |
CHF-6523
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CHF-6523 is an inhaled PI3Kδ inhibitor. |
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DC66712 |
BAY-2413555
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DC66713 |
NVP-EVS459
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DC60642 |
Compound 33 (HYOU1 inhibitor)
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Compound 33 (HYOU1 inhibitor) is a first-in-class inhibitor of hypoxia up-regulated protein 1 (HYOU1) with EC50 of 3.2 μM/2.6 μM/16.1 μM/3.0 μM in WT-MIP3/WT-RANTES/hTNFtg-MIP3/hTNFtg-RANTES, respectively. |
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DC60643 |
BRD-810
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BRD-810 is a potent and selective MCL1 inhibitor with Kd of 0.3 nM (SPR) and IC50 of 0.4 nM (MCL1-Noxa HTRF), respectively. BRD-810 is a rapidly cleared inhibitor of MCL1 that has robust antitumor efficacy in hematological and solid tumor cancer models. |
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