| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC26096 | SR-8993 | A potent, highly selective, brain-penetrant NOP-R (Nociceptin/orphanin FQ receptor) agonist with EC50 of 8.8 nM. |
|
| DC11609 | VU6010608 | A potent, highly selective, CNS penetrant mGlu7 negative allosteric modulator with IC50 of 0.76 uM. |
|
| DC11725 | BI-0252 | A potent, highly selective, orally active MDM2-p53 interaction inhibitor with IC50 of 4 nM. |
|
| DC20316 | Bantag-1 trifluoroacetate Featured | A potent, highly selective, peptide bombesin receptor subtype-3 (BRS-3) antagonist with IC50 of 2-8 nM for human and rodent BRS-3, displays 1000-fold selectivity over hNMBR and hGRPR, increases food intake and produces an obesity phenotype in mice.. |
|
| DC11736 | PF-956980 | A potent, highly specific JAK3 inhibitor with IC50 of 4 nM. |
|
| DC21861 | Z-DON | A potent, irreversible and cell permeable inhibitor of tissue transglutaminase with IC50 of 20 nM.. |
|
| DC21216 | L 682777 | A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC23777 | R 283 | A potent, irreversible inhibitor of human tissue transglutaminase (hTG2).. |
|
| DC21001 | Estrone sulfamate | A potent, irreversible, and orally active inhibitor of steroid sulfatase (STS) with IC50 of 65 pM in intact MCF-7 cells. |
|
| DC22880 | MIV-6R | A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM. |
|
| DC22383 | Sitaxsentan | A potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43 nM, IC50 of 1.4 nM. |
|
| DC23661 | Evogliptin | A potent, long acting, reversible and competitive DPP-4 inhibitor with IC50 of 0.9 nM. |
|
| DC22890 | Frovatriptan Featured | A potent, long lasting 5-HT(1B/1D) receptor agonist as a antimigraine agent.. |
|
| DC11758 | PB 28 dihydrochloride Featured | A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively. |
|
| DC11757 | PB 28 | A potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively. |
|
| DC22812 | CEP-11981 | CEP-11981 is a potent, multi-targeted, orally active, pan-VEGFR, TIE-2 and FGFR1 inhibitor with IC50 of 3-100 nM. |
|
| DC22851 | IDI-6273 | A potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH. |
|
| DC20946 | DD-01050 | A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity. |
|
| DC24010 | Plpro-IN-6(PLpro inhibitor) Featured | A potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 2.6 uM. |
|
| DC22706 | BMY 45778 Featured | A potent, non-prostanoid prostacyclin partial agonist that potently inhibits human (IC50=35 nM), rabbit (IC50=136 nM) and rat (IC50=1.3 uM) platelet aggregation. |
|
| DC22815 | K252a | A potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases. |
|
| DC20615 | A 834735 | A potent, nonselective, brain penetrant, full agonist at both the central CB1 and peripheral CB2 receptors with Ki of 4.6 and 0.31 nM, respectively. |
|
| DC22899 | MK-3577 | A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM. |
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| DC23709 | FXR-sHE modulator 57 | A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4). |
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| DC23968 | GAP-134 hydrochloride | A potent, orally active gap-junction modifier. |
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| DC23969 | GAP-134 | A potent, orally active gap-junction modifier. |
|
| DC20972 | DS79182026 | A potent, orally active hepcidin production inhibitor with IC50 of 39 nM, with low kinase inhibitory activity. |
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| DC20694 | ASP 9853 | A potent, orally active iNOS inhibitor (IC50=10 nM, NO release DLD-1 cells) that prevents dimerization of iNOS, but has no effect on the expression or enzyme activity of iNOS. |
|
| DC22737 | CP-346086 Featured | A potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM. |
|
| DC21627 | SC-806 | A potent, orally active p38 MAPK inhibitor with IC50 of 50 nM, significantly decreases incidence of arthritis in mouse collagen-induced arthritis.. |
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