Cat. No. | Product name | CAS No. |
DC3168 |
PF-562271 PHSO3H SALT
Featured
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. |
939791-38-5 |
DC7059 |
PF-03758309
Featured
PF-03758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. |
898044-15-0 |
DC7081 |
PF-04217903
Featured
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). |
956905-27-4 |
DC8353 |
PF-04418948
Featured
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). |
1078166-57-0 |
DC11367 |
PF-04447943
Featured
PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis. |
1082744-20-4 |
DC7027 |
Glasdegib(PF-04449913)
Featured
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor |
1095173-27-5 |
DC7227 |
PF-04620110
Featured
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
1109276-89-2 |
DC3108 |
PF-04971729 (Ertugliflozin)
Featured
PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. |
1210344-57-2 |
DC9915 |
PF04995274,PF 04995274
Featured
PF-04995274 is a 5-HT4 receptor partial agonist. It thought to act centrally as a pro-cognitive agent that being developed for the treatment of Alzheimer's disease (AD). |
1331782-27-4 |
DC10050 |
PF05175157
Featured
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. |
1301214-47-0 |
DC11937 |
PF 05180999
Featured
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
1394033-54-5 |
DC11734 |
PF-06263276
PF-06263276 (PF06263276, PF 6263276) is a potent, selective pan JAK inhibitor with IC50 of 2.2, 23.1, 59.9 and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively. |
1421502-62-6 |
DC10631 |
PF-06273340
PF-06273340 is a highly potent, kinases elective, well-tolerated pan-Trk inhibitor with IC50 values of 6, 4, 3 nM for TrkA, TrkB, Trk C, respectively. |
1402438-74-7 |
DC10500 |
PF-06282999
Featured
PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potential useful for the treatment of cardiovascular diseases. |
1435467-37-0 |
DC11466 |
PF-06409577
Featured
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. |
1467057-23-3 |
DC11722 |
PF-06459988
PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. |
1428774-45-1 |
DC7924 |
PF06463922(Lorlatinib)
Featured
PF06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. |
1454846-35-5 |
DC10779 |
PF-06651600
Featured
PF-06651600 is a potent JAK3-selective inhibitor with an IC50 of 33.1 nM. |
1792180-81-4 |
DC12488 |
PF-06700841 tosylate
Featured
PF-06700841 is an inhibitor of JAK1 and TYK2 kinases. PF-06700841 has been investigated for the treatment of psoriasis and lupus. |
2140301-96-6 |
DC10022 |
PF06840003
Featured
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities. |
198474-05-4 |
DC2047 |
Crizotinib (PF-2341066)
Featured
PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nnM, respectivley. |
877399-52-5 |
DC7201 |
PF-2545920(MP-10)
Featured
PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM. |
898562-94-2 |