Cas No.: | 2098711-72-7 |
Chemical Name: | 5-(4-((3-chlorobenzyl)amino)-2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)quinazolin-6-yl)-1-methylpyridin-2(1H)-one |
Synonyms: | CN-750;CN 750 |
SMILES: | C(=O)1N(C)C=C(C2C=CC3C(C=2)=C(NCC2=CC=CC(Cl)=C2)N=C(N2CCN(CCN(C)C)CC2)N=3)C=C1 |
Formula: | C29H34ClN7O |
M.Wt: | 532.089 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM; shows Kd values of 33, 27, 24, 21, 20, 21, 18, 50, 20, 67, and 160 nM for BRD2 (BD1), BRD2 (BD1,2), BRD2 (BD2), BRD3 (BD1), BRD3 (BD1,2), BRD3 (BD2), BRD4 (BD1), BRD4 (BD2), BRDT (BD1), BRDT (BD1,2), and BRDT (BD2), respectively; CN750 is a pan BET family inhibitor. |