AZ-27|AZ27;AZ 27

Cas No.:	1516772-44-3
Chemical Name:	6-(4-(2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-N-cyclopropyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide
Synonyms:	AZ27;AZ 27
SMILES:	N(C(=O)C1=CC=C(NC(=O)C2=C(N3CCC4(COC4)CC3)N=CC=C2)C=C1)1CCC2C=C(C(NC3CC3)=O)SC=2C2=CC=CC=C12
Formula:	C₃₆H₃₅N₅O₄S
M.Wt:	633.767
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent non-nucleoside RSV L-protein polymerase inhibitor with EC50 of 0.01 uM and 1.3 uM for RSV A2 and RSV B-WST, respectively; exhibits high potency against the RSV A subtype (average EC50=24±9 nM) than against the B subtype (average EC50=1.0±0.28 uM); shows no cytotoxicity.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47013	(S)-Enzaplatovir	(S)-Enzaplatovir ((S)-BTA-C585) is the S-enantiomer of Enzaplatovir. (S)-Enzaplatovir shows antiviral activities with an EC50 of 56 nM for respiratory syncytial viral (RSV) (patent WO2011094823A1 compound 77).
DC41364	ent-11β-Hydroxyatis-16-ene-3,14-dione	ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity.
DC40330	Quercetin pentaacetate	Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface.
DC9618	TMC353121	TMC353121 is a potent RSV fusion inhibitor with pEC50 of 9.9(t1/2 in lung = 25 h).
DC10435	RSV604 racemate	RSV604 racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
DC11774	YM-53403	A specific anti-respiratory syncytial virus (RSV) agent with EC50 of 0.2 uM in plaque reduction assays.
DC11773	BI Compound D	A potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 89 nM.
DC11771	AZ-27	A potent non-nucleoside RSV L-protein polymerase inhibitor with EC50 of 0.01 uM and 1.3 uM for RSV A2 and RSV B-WST, respectively.