Cat. No. | Product name | CAS No. |
DC7993 |
Prexasertib (LY2606368) 2HCl
Featured
LY2606368 2Hcl is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. |
1234015-54-3 |
DC10796 |
Prexasertib (LY2606368)
Featured
LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. |
1234015-52-1 |
DC8643 |
LY2835219 free base (Abemaciclib)
Featured
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. |
1231929-97-7 |
DC5062 |
LY2835219(Abemaciclib)
Featured
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. |
1231930-82-7 |
DC9766 |
LY3177833
Featured
LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM. |
1627696-51-8 |
DC12261 |
LY3295668 (AK-01)
LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. |
1919888-06-4 |
DC9741 |
Mad2 inhibitor-1 (M2I-1)
Featured
Mad2 Inhibitor-1 (M2I-1) is a small molecule protein-protein interaction inhibitor targeting the mitotic spindle assembly checkpoint. |
312271-03-7 |
DC11141 |
ME0328
Featured
ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression. |
1445251-22-8 |
DC9050 |
Melphalan
Featured
Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. |
148-82-3 |
DC4182 |
Temozolomide
Featured
Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
85622-93-1 |
DC8935 |
Mitomycin C
Featured
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. |
50-07-7 |
DC1070 |
MK-1775(AZD-1775,Adavosertib)
Featured
MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM. |
955365-80-7 |
DC4179 |
Niraparib(MK4827) free base
Featured
MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. |
1038915-60-4 |
DC9862 |
Niraparib(MK4827) hydrochloride
Featured
MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. |
1038915-64-8 |
DC9576 |
Niraparib tosylate
Featured
MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1. |
1038915-73-9 |
DC7466 |
MK-5108
MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM; 220- and 190-fold more selective for Aurora A than Aurora B/C. |
1010085-13-8 |
DC8594 |
ML167
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. |
1285702-20-6 |
DC7771 |
ML216
Featured
ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. |
1430213-30-1 |
DC9365 |
MLN8054
Featured
MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM; exhibits more than 40-fold selective for Aurora A than Aurora B. |
869363-13-3 |
DC2016 |
MLN8237 (Alisertib)
Featured
MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM. |
1028486-01-2 |
DC8659 |
MN-64
Featured
MN-64 is a inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. |
92831-11-3 |
DC7470 |
MPI-0479605
Featured
MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. |
1246529-32-7 |