Cat. No. | Product name | CAS No. |
DC5059 |
IWP-3
Featured
IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. |
687561-60-0 |
DC7053 |
IWR-1
Featured
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
1127442-82-3 |
DCAPI1510 |
Ixabepilone
Featured
Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
219989-84-1 |
DC7435 |
J-147
Featured
J-147 is a potent neuroprotective and neurotrophic compound. |
1146963-51-0 |
DC20641 |
J8-C8
Featured
J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production. |
1150565-77-7 |
DC11136 |
JAK2 inhibitor G5-7
Featured
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
939681-36-4 |
DC8077 |
WHI-P131(Janex 1)
Featured
Janex 1 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM). |
202475-60-3 |
DC10095 |
JD5037
Featured
JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM). |
1392116-14-1 |
DC9621 |
Jervine
Featured
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. |
469-59-0 |
DC8379 |
JH-II-127
Featured
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
1700693-08-8 |
DC22122 |
JI051
Featured
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
2234281-75-3 |
DC10123 |
JI-101
Featured
JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
900573-88-8 |
DC7437 |
JIB-04
Featured
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
199596-05-9 |
DC9929 |
JK-184
Featured
JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). |
315703-52-7 |
DC10595 |
JK-P3
Featured
JK-P3 is a VEGFR-2 inhibitor. |
942655-44-9 |
DC10971 |
JMS-17-2
Featured
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
1380392-05-1 |
DC21167 |
JMV 2959
Featured
JMV 2959 (AEZS-123) is a potent ghrelin receptor (GHS-R1A) antaognist with binding IC50 of 32 nM. |
925238-89-7 |
DC12804 |
JND3229
Featured
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). |
2260886-64-2 |
DC7843 |
JNJ 42153605
Featured
JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
1254977-87-1 |
DC11404 |
JNJ0966
Featured
JNJ0966 is a highly selective compound that inhibited activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. |
315705-75-0 |
DC12374 |
JNJ-10229570
Featured
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
524923-88-4 |
DC22665 |
JNJ18038683
Featured
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
851376-05-1 |