| DC7731 |
Emapunil(AC-5216)
Featured
|
Emapunil(AC-5216;XBD-173) is a translocator protein |
|
| DC9620 |
EMD638683
Featured
|
EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM. |
|
| DC8885 |
EMICORON
Featured
|
EMICORON is a novel G-quadruplex (G4) ligand showing high selectivity for G4 structures over the duplex DNA, causing telomere damage and inhibition of cell proliferation in transformed and tumor cells. |
|
| DC9771 |
ACU4429,ACU 4429,ACU-4429
Featured
|
Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. |
|
| DC10301 |
Emodepside
Featured
|
Emodepside (PF 1022-221) is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. |
|
| DC5018 |
Empagliflozin (BI-10773)
Featured
|
Empagliflozin is a potent, selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes. Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), which is found almost exclusively in |
|
| DC23171 |
Empesertib(BAY 1161909)
Featured
|
Empesertib (BAY-1161909, BAY1161909) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.34 nM. |
|
| DC9762 |
Emricasan
Featured
|
Emricasan (IDN-6556, PF-03491390) is a potent irreversible pan-caspase inhibitor. |
|
| DC5902 |
Emtricitabine
Featured
|
Emtricitabine is a nucleoside analogue which inhibits the reverse nucleoside transcriptase enzyme. Structurally this antiviral agent is similar to Lamivudine. This agent is effective at targeting HIV and HBV viruses since these viruses replicate in a reve |
|
| DC23108 |
EN460
Featured
|
EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM). |
|
| DC24204 |
EN6
Featured
|
EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase, which activates mTORC1 via the Rag guanosine triphosphatases. |
|
| DC8177 |
Enclomiphene citrate
Featured
|
Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. |
|
| DC9959 |
Endoxifen (E-isomer)
Featured
|
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). |
|
| DC8403 |
Endoxifen (Z-isomer hydrochloride)
Featured
|
Endoxifen HCl, the active metabolite of Tamoxifen, ia a potent and selective estrogen receptor antagonist. Phase 2. |
|
| DC8265 |
Endoxifen
Featured
|
Endoxifen is a Estrogen receptor α (ERα) ligand; potent antiestrogen,an active metabolite of the cancer drug tamoxifen. |
|
| DC7589 |
Eniporide(EMD96785)
Featured
|
Eniporide is a The Na(+)/H(+) exchange inhibitor. |
|
| DC20993 |
ENMD-1068
Featured
|
ENMD-1068 is a novel selective PAR2 antagonist without inhibitory activity against thrombin-mediated PAR3 and PAR4 signaling. |
|
| DC7118 |
ENMD-2076
Featured
|
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. |
|
| DC9247 |
AP-III-a4 hydrochloride
Featured
|
ENOblock Hcl(AP-III-a4 Hcl) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. |
|
| DC7119 |
ENO block(AP-III-a4)
Featured
|
ENOblock(AP-III-a4) is a novel small molecule which is the first, nonsubstrate analogue that directly binds to enolase and inhibits its activity (IC50=0.576 uM); inhibit cancer cell metastasis in vivo. |
|
| DC20018 |
Enocyanin
Featured
|
Enocyanin is an anthocyanin extracted from grapes. Enocyanin shows inhibitory effect on the leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase and esterase activity. |
|
| DC10547 |
Ensartinib
Featured
|
Ensartinib is a potent inhibitor of ALK, which is used to treat non-small-cell lung cancer. |
|
| DC8321 |
Entacapone
Featured
|
Entacapone is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment. |
|
| DC4208 |
Entecavir Monohydrate
Featured
|
Entecavir hydrate belongs to the family of medicines called antivirals. |
|
| DC6909 |
Entinostat (MS-275)
Featured
|
Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2. |
|
| DC24202 |
Ent-kaurene
Featured
|
Ent-kaurene is a tetracyclic diterpene consisting of ent-kaurane, where the 6-methyl group is replaced by methylene. It derives from a hydride of an ent-kaurane. |
|
| DC8300 |
Entrectinib (RXDX-101)
Featured
|
Entrectinib (RXDX-101), a potent and selective small molecule inhibitor of TrkA/B/C, ROS1, and ALK kinases, has demonstrated early clinical activity when orally administered intermittently under fasting conditions. |
|
| DC5057 |
Enzastaurin (LY317615)
Featured
|
Enzastaurin (LY317615) is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. Phase 3. |
|
| DC8389 |
Epacadostat (INCB024360)
Featured
|
Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. Phase 2. |
|
| DCAPI1356 |
Epalrestat
Featured
|
Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy. |
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