| DC11287 |
EHT 5372
Featured
|
EHT 5372 is a novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. |
|
| DC7930 |
EI-1
Featured
|
EI1 is a potent and selective small molecule inhibitor of EZH2 with IC50 values of 15 nM and 13 nM for wild type EZH2 and EZH2 Y641F mutant, respectively. |
|
| DC12233 |
Eicosadienoic acid
Featured
|
Eicosadienoic acid is a rare, naturally occurring n-6 polyunsaturated fatty acid found mainly in animal tissues. |
|
| DC9684 |
EL102
Featured
|
EL-102 is a dual-inhibitor of apoptosis and angiogenesis, and exerts its action though the inhibition of Hif1 alpha induced hypoxic signalling pathways and induction of the Caspase 3/7 apoptotic cascade. |
|
| DC10182 |
Elacestrant (dihydrochloride)
Featured
|
Elacestrant dihydrochloride (RAD1901 dihydrochloride) is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
|
| DC8301 |
Elacridar
Featured
|
Elacridar is an orally selectly potent P-glycoprotein (P-gp/ABCG1) inhibitor. |
|
| DC10727 |
Elafibranor(GFT505)
Featured
|
Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with EC50 values of 45 and 175 nM, respectively. |
|
| DC10032 |
Elagolix sodium
Featured
|
Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. |
|
| DC7407 |
Elagolix
Featured
|
Elagolix is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. |
|
| DC9295 |
Elbasvir(MK-8742)
Featured
|
Elbasvir (MK-8742) is a small-molecule inhibitor of nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) being developed as a component of treatment regimens for chronic HCV infection. |
|
| DCAPI1410 |
Eldecalcitol
Featured
|
Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density. Eldecalcitol (ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3) is more efficaci |
|
| DC9980 |
Eleclazine(GS-6615)
Featured
|
Eleclazine(GS-6615) is a selective late sodium current inhibitor. |
|
| DC11551 |
Elenbecestat
Featured
|
Elenbecestat (E2609) is a novel potent, oral BACE1 inhibitor for treatment of Alzheimer's disease.. |
|
| DC3156 |
Elesclomol (STA-4783)
Featured
|
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells.. |
|
| DC8323 |
Eletriptan HBr
Featured
|
Eletriptan HBr is an orally active, selective 5-HT1B/1D receptor agonist. |
|
| DC9291 |
Eliglustat hemitartrate (Genz-112638)
Featured
|
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase. |
|
| DC9290 |
Eliglustat(Genz-99067)
Featured
|
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase. |
|
| DC8268 |
Eliprodil
Featured
|
Eliprodil is a non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. |
|
| DC10410 |
Ellipticine hydrochloride
Featured
|
Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities. |
|
| DC8325 |
Ellipticine
Featured
|
Ellipticine is a DNA intercalating agent and a DNA topoisomerase II inhibitor. |
|
| DC7786 |
ELN 441958
Featured
|
ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958 is highly selective for B1 over B2 receptors, and >500/ 2000-fold selective for the B1 over μ/δ-opioid receptor.IC50 value: 0.26 nM (Ki)Target: B1 Receptorin vitro: ELN-441958 is a novel small molecule bradykinin B1 receptor antagonist, based on the inhibition of agonist-induced increases in intracellular calcium in native and recombinant cells. ELN-441958 does not inhibit the activation of the human bradykinin B2 receptor at concentrations up to 10 μM, showing that it is highly selective for B1 over B2 receptors. ELN-441958 also displays good selectivity for B1 over other receptors examined in a broad screening panel. It is >500-fold and >2000-fold selective for the B1 receptor over the human μ- and δ-opioid receptor, the most potent off-target activity identified. In IMR-90 cells expressing the native human B1 receptor, ELN-441958 produced a concentration-dependent antagonism of the DAKD-induced calcium mobilization with a KB of 0.12 nM. [1]in vivo: ELN-441958 is essentially completely absorbed and produces high plasma levels after oral administration in rhesus monkeys.ELN-441958 has a moderate clearance and volume of distribution in both species following i.v. administration, consistent with the high metabolic stability in rat, rhesus, and human microsomes. ELN-441958 has high oral exposure and moderate plasma half-lives in rats and rhesus monkeys. The oral availability of ELN441958 in rats was 57%. ELN-441958 dose-dependently reduced carrageenan-induced thermal hyperalgesia in a rhesus monkey tail-withdrawal model, with an ED50 3 mg/kg s.c. [1] |
|
| DC10740 |
ELN484228
Featured
|
ELN484228 is a blocker of α-synuclein which is a key protein in Parkinson’s disease. |
|
| DC20268 |
ELQ300
Featured
|
ELQ300 is a novel inhibitor of the mitochondrial cytochrome bc1 complex (complex III in the electron transport chain). |
|
| DCAPI1196 |
Eltrombopag (SB-497115-GR)
Featured
|
Eltrombopag (SB-497115-GR) |
|
| DC8369 |
Eltrombopag olamine
Featured
|
Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. |
|
| DC8625 |
Eluxadoline Dihydrochloride
Featured
|
Eluxadoline Dihydrochloride is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. |
|
| DC8626 |
Eluxadoline
Featured
|
Eluxadoline is an orally active mixed μ opioid receptor (μOR) agonist δ opioid receptor (δOR) antagonist. |
|
| DC4235 |
Elvitegravir（GS9137）
Featured
|
Elvitegravir (EVG) is a drug used for the treatment of HIV infection. It acts as an integrase inhibitor. |
|
| DC10870 |
EMA400
Featured
|
EMA400 is a potent and highly selective AT2R antagonist. |
|
| DC10869 |
Olodanrigan(EMA401)
Featured
|
EMA401(Olodanrigan) is a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. |
|
