| DC8154 |
FRAX 597
Featured
|
FRAX597 is a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. |
|
| DC23050 |
fraxinellone
Featured
|
Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities. |
|
| DC7902 |
Fruquintinib (HMPL-013)
Featured
|
Fruquintinib (HMPL-013) is a novel small molecule compound that selectively inhibits vascular endothelial growth factor receptors (VEGFRs). |
|
| DC20272 |
FT113
Featured
|
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. |
|
| DC11554 |
FT-671
Featured
|
FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain). |
|
| DC11029 |
FTBMT
Featured
|
FTBMT is a novel selective GPR52 agonist of GPR52, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively. |
|
| DC8421 |
FTI 277 HCl
Featured
|
FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. |
|
| DC3154 |
Fingolimod HCl（FTY-720）
Featured
|
FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
|
| DC11394 |
Fulacimstat(BAY 1142524)
Featured
|
Fulacimstat(BAY 1142524) is a small molecule chymase inhibitor. |
|
| DC4200 |
Fulvestrant
Featured
|
Fulvestrant is an estrogen receptor (ER) antagonist with IC50 of 0.094 nM. |
|
| DC8855 |
Fumagillin
Featured
|
Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis. |
|
| DCAPI1020 |
Fumalic acid (Ferulic acid)
Featured
|
Fumalic acid (Ferulic acid) |
|
| DC11235 |
Furamidine dihydrochloride
Featured
|
Furamidine dihydrochloride (NSC 305831) tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM. |
|
| DC10447 |
FX1
Featured
|
FX1 is a novel specific inhibitor of the B cell lymphoma 6 (BCL6). |
|
| DC8222 |
G007-LK
Featured
|
G007-LK is a potent, "rule of 5" compliant and a metabolically stable TNKS1/2 inhibitor. |
|
| DC24027 |
STING Agonist-1(G-10)
Featured
|
G10 (STING Agonist 1) is a novel human-specific STING agonist. |
|
| DC10814 |
G-15
Featured
|
G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM). |
|
| DC10501 |
G1T28(Trilaciclib)
Featured
|
G1T28(Trilaciclib) is a potential first-in-class, short-acting IV CDK4/6 inhibitor being developed to preserve hematopoietic stem cells and enhance immune system function during chemotherapy. |
|
| DC10816 |
G-36
Featured
|
G-36 is a cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1(IC50 = 112 and 165 nM, respectively). |
|
| DC12438 |
G6PD activator AG1
Featured
|
G6PD activator AG1 (AG1) is a specific, small molecule that increases the activity of the wild-type, Canton mutant (R459L, EC50=3 uM) and several other common G6PD mutants; displays no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6PGD, GAPDH, ALDH2, and ALDH3A1; attenuates ROS-induced pericardial edema in a G6PD-dependent manner in zebrafish, reduces hemolysis of human erythrocytes |
|
| DC7792 |
G-749
Featured
|
G-749 is an inhibitor of Fms-like tyrosine receptor kinase 3 (FLT3) with IC50 values ranging from 2.1 to 38.1 nM for wild-type and mutant (constitutively active) FLT3s in Ba/F3 cells expressing recombinant receptors. |
|
| DC8954 |
Gabapentin
Featured
|
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. |
|
| DCAPI1037 |
Gadodiamide (Omniscan)
Featured
|
Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Target: OthersGadodiamide(Omniscan) is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is a contrast medium for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. The product provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). A recent review takes the question of toxicity caused by loss of gadolinium from the complex. "The challenge for nephrologists includes (a) evidence of transmetallation, such as gadolinium deposits in bone, increased urinary zinc excretion, iron-transferrin dissociation or 'spurious hypocalcemia' in exposed people"。 |
|
| DC11053 |
GAK inhibitor 49
Featured
|
GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K). |
|
| DC9859 |
GAL-021
Featured
|
GAL-021 is a new intravenous BKCa-channel blocker. |
|
| DC7861 |
(-)-Narwedine
Featured
|
Galantamine(Narwedin) is a competitive and reversible cholinesterase(AChE) inhibitor. |
|
| DC10133 |
Gambogic Acid
Featured
|
Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. |
|
| DC21197 |
Ganaplacide
Featured
|
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains. |
|
| DC7320 |
Ganetespib(STA-9090)
Featured
|
Ganetespib(STA-9090) is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells. |
|
| DC8877 |
Ganirelix
Featured
|
Ganirelix is a man-made form of a protein that reduces the amount of certain hormones in the body, including estrogen. |
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