| DC8379 |
JH-II-127
Featured
|
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
|
| DC22122 |
JI051
Featured
|
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
|
| DC10123 |
JI-101
Featured
|
JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
|
| DC7437 |
JIB-04
Featured
|
JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
|
| DC9929 |
JK-184
Featured
|
JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). |
|
| DC10595 |
JK-P3
Featured
|
JK-P3 is a VEGFR-2 inhibitor. |
|
| DC10971 |
JMS-17-2
Featured
|
JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
|
| DC21167 |
JMV 2959
Featured
|
JMV 2959 (AEZS-123) is a potent ghrelin receptor (GHS-R1A) antaognist with binding IC50 of 32 nM. |
|
| DC12804 |
JND3229
Featured
|
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). |
|
| DC7843 |
JNJ 42153605
Featured
|
JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
|
| DC11404 |
JNJ0966
Featured
|
JNJ0966 is a highly selective compound
that inhibited activation of MMP-9 zymogen and subsequent
generation of catalytically active enzyme. |
|
| DC12374 |
JNJ-10229570
Featured
|
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
|
| DC22665 |
JNJ18038683
Featured
|
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
|
| DC7175 |
JNJ-26854165 (Serdemetan)
Featured
|
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
|
| DC23567 |
JNJ303
Featured
|
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents). |
|
| DC8140 |
JNJ31020028
Featured
|
JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07, human; pIC50=8.22 rat); >100-fold selective versus human Y1/Y4/Y5 receptors. |
|
| DC7177 |
JNJ 38877605
Featured
|
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases. |
|
| DC8617 |
JNJ-42041935
Featured
|
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. |
|
| DC9662 |
JNJ-42165279
Featured
|
JNJ-42165279 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70nM. |
|
| DC22125 |
JNJ4796
Featured
|
JNJ4796 (JNJ 4796, JNJ-4796) is an orally active small-molecule fusion inhibitor of influenza virus hemagglutinin (HA) with EC50 of 33 nM (H1N1 neutralization). |
|
| DC21180 |
JNJ-47965567
Featured
|
JNJ-47965567 is a potent, selective, centrally permeable P2X7 receptor antagonist with pKi of 7.9 and 8.7 for human and rat P2X7, respectively. |
|
| DC12166 |
JNJ-5207852
Featured
|
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. |
|
| DC21170 |
JNJ525
Featured
|
JNJ525 is a small molecule inhibitor that targets tumor necrosis factor alpha (TNFα), a cytokine involved in inflammation and immune regulation. TNFα exerts its biological effects by binding to its receptors, TNFR1 (TNF receptor 1) and TNFR2 (TNF receptor 2). JNJ525 works by preventing the formation of TNFα complexes with these receptors, thereby inhibiting TNFα-mediated signaling pathways. |
|
| DC21182 |
JNJ-53718678
Featured
|
JNJ-53718678 (JNJ53718678, JNJ-678) is a potent (Kd=7.4 nM), small-molecule inhibitor of the F-glycoprotein-mediated complex membrane fusion process of the RSV. |
|
| DC12271 |
JNJ-54175446
Featured
|
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
|
| DC10882 |
JNJ-632
Featured
|
JNJ-632 is a novel and potent inhibitor of HBV replication in vitro across genotypes A-D. |
|
| DC9271 |
JNJ-63533054
Featured
|
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
|
| DC7178 |
JNJ-7706621
Featured
|
JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6; also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. |
|
| DC8773 |
JNJ-7777120
Featured
|
JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. |
|
| DC22516 |
Unii-cedo9qxyzk
Featured
|
JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2. |
|
