| DC5107 |
SB-715992 (Ispinesib)
Featured
|
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
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| DC8772 |
Isradipine
Featured
|
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM. |
|
| DC7431 |
ISRIB
Featured
|
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM. |
|
| DC22333 |
iST2-2
Featured
|
iST2-2 is a novel ST2 (suppression of tumorigenicity 2) inhibitor active in vivo. |
|
| DCAPI1080 |
Istradefylline (KW-6002)
Featured
|
Istradefylline(KW6002) is a very potent, selective and orally active adenosine A2A receptor antagonist(Ki=2.2 nM) in experimental models of Parkinson's disease. |
|
| DC8304 |
Isoxazole 9(ISX9)
Featured
|
ISX-9 is a small molecule inducer of adult neural stem cell differentiation both in vitro and in vivo. |
|
| DC10898 |
Protein kinase inhibitor 1
Featured
|
It is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM. |
|
| DC10768 |
IT 901
Featured
|
IT 901 is a c-Rel inhibitor (IC50 = 3 μM). Inhibits IL-2 expression in activated T-cells in vitro. |
|
| DC10283 |
IT1t dihydrochloride
Featured
|
IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. |
|
| DC12378 |
Itacitinib(INCB039110)
Featured
|
Itacitinib is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis. |
|
| DC8028 |
ITD-1
Featured
|
ITD-1 is a novel and highly selective TGFβ pathway inhibitor. ITD-1 molecule turns stem cells into heart cells. |
|
| DC23662 |
ITI214 free base
Featured
|
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
|
| DC10220 |
ITSA-1 (ITSA1)
Featured
|
ITSA-1 (ITSA1) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. |
|
| DC21157 |
ITX-5061 hydrochloride
Featured
|
ITX-5061 is a scavenger receptor B1 antagonist that promotes high-density lipoprotein (HDL) levels. |
|
| DC26005 |
IU1
Featured
|
IU1 is a selective USP14 inhibitor. IU1 prevents ventilator-induced lung injury in rats. |
|
| DC23797 |
IU1-47
Featured
|
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons. |
|
| DC3153 |
Ivabradine hydrochloride
Featured
|
Ivabradine, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. |
|
| DC4128 |
Ivacaftor (VX-770)
Featured
|
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
|
| DC7434 |
IWP-L6
Featured
|
IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM. |
|
| DC5028 |
IWP-2
Featured
|
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. |
|
| DC5059 |
IWP-3
Featured
|
IWP-3 is a selective small molecule wnt inhibitor, prevents palmitylation of Wnt proteins by Porcupine (Porcn), a membrane-bound O-acyltransferase, thereby blocking Wnt secretion and activity1. |
|
| DC7053 |
IWR-1
Featured
|
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
|
| DCAPI1510 |
Ixabepilone
Featured
|
Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
|
| DC7435 |
J-147
Featured
|
J-147 is a potent neuroprotective and neurotrophic compound. |
|
| DC20641 |
J8-C8
Featured
|
J8-C8 is a small-molecule inhibitor of bacterial N-acyl-homoserine lactone synthase (acyl-HSLs) TofI with IC50 of 35 uM for toxoflavin production. |
|
| DC11136 |
JAK2 inhibitor G5-7
Featured
|
JAK2 inhibitor G5-7 is a small molecule, allosteric JAK2 inhibitor that selectively inhibits JAK2-mediated phosphorylation and activation of EGFR and STAT3 by binding to JAK2. |
|
| DC8077 |
WHI-P131(Janex 1)
Featured
|
Janex 1 selectively inhibits the tyrosine kinase activity of JAK3 with an IC50 value of 78 µM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases (IC50 ≥350 µM). |
|
| DC10095 |
JD5037
Featured
|
JD5037 is an inverse agonist of peripheral cannabinoid 1 (CB1) receptors (Ki = 0.35 nM). |
|
| DC9621 |
Jervine
Featured
|
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
|
|
| DC8379 |
JH-II-127
Featured
|
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor. |
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