| DC8927 |
Liraglutide
Featured
|
Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus. |
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| DC12433 |
LIT-001
Featured
|
LIT-001 (LIT001) is the first nonpeptide Oxytocin receptor (OT-R) agonist with EC50 of 55 nM, Emax=96%. |
|
| DC12434 |
LIT-001 trifluoroacetate
Featured
|
LIT-001 trifluoroacetate (LIT001) is the first nonpeptide Oxytocin receptor (OT-R) agonist with EC50 of 55 nM, Emax=96%. |
|
| DC4138 |
Lixivaptan (VPA-985)
Featured
|
Lixivaptan is a highly potent, non-peptide, oral capsule that works by reducing the action of a hormone (vasopressin) that blocks fluid excretion. |
|
| DC21233 |
LJ 001
Featured
|
LJ 001 ((LJ-001, LJ001) is a broad-spectrum antiviral agent targeting entry of enveloped viruses, including influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1; specifically intercalates into viral membranes, irreversibly inactivates virions while leaving functionally intact envelope proteins, and inhibits viral entry at a step after virus binding but before virus-cell fusion; specifically inhibits virus-cell but not cell-cell fusion |
|
| DC8811 |
LJH-685
Featured
|
LJH685 is a selective and potent RSK inhibitor. |
|
| DC8812 |
LJI-308
Featured
|
LJI308 is a selective and potent RSK inhibitor. |
|
| DC21240 |
LLY-283
Featured
|
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM. |
|
| DC7856 |
LLY-507
Featured
|
LLY-507 is a chemical probe for SMYD2 (a protein lysine methyltransferase). |
|
| DC10758 |
LM22B-10
Featured
|
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo. |
|
| DC10892 |
LMI070 (NVS-SM1)
Featured
|
LMI070 (NVS-SM1) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
|
| DC4241 |
LMK-235
Featured
|
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor (IC50 values are 4.22, 11.9, 55.7, 320, 852, 881, and 1278 nM for HDAC 5, 4, 6, 1, 11, 2, and 8, respectively). |
|
| DC20259 |
LML134
Featured
|
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1]. |
|
| DC20275 |
LMP-744 hydrochloride
Featured
|
LMP744(Mj-III-65,NSC-706744) is a DNA intercalator and topoisomerase inhibitor with antitumor activity. |
|
| DC10836 |
LMPTP inhibitor 23
Featured
|
LMPTP inhibitor 1 is a potent molecule for diabetes which can increase liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes by inhibiting the IR phosphatase LMPTP. |
|
| DC12602 |
LMT-28
Featured
|
LMT-28 (LMT28) is a specific blocker of IL-6 signaling via inhibits IL-6Rβ (gp130) with IC50 of 5.9 uM (IL-6–induced luciferase activity), selectively inhibits IL-6–induced phosphorylation of STAT3, JAK2, and gp130. |
|
| DC25003 |
LOC14
Featured
|
LOC-14 is a small molecule reversible Protein disulfide isomerase (PDI) inhibitor with Kd of 62 nM. |
|
| DC10188 |
Lodoxamide
Featured
|
Lodoxamide is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis. |
|
| DC10694 |
Loflucarban
Featured
|
Loflucarban is an antiinfective drug |
|
| DC7188 |
Lomeguatrib(PaTrin-2)
Featured
|
Lomeguatrib (PaTrin-2) is a modified guanine base, which can repress the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) with an IC50 value of 6 nM. |
|
| DC7778 |
Lometrexol(LY 264618)
Featured
|
Lometrexol is a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase (GARFT), was the first GARFT inhibitor to be investigated clinically. |
|
| DC7900 |
AEGR-733(Lomitapide)
Featured
|
Lomitapide (AEGR-733) is a novel proprietary MTP-inhibitor. |
|
| DC7455 |
Lonafarnib
Featured
|
Lonafarnib(Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. |
|
| DCAPI1199 |
Lonidamine
Featured
|
Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis. |
|
| DC8907 |
Lopinavir
Featured
|
Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM,showed potent activity against COVID-19(SARS-COV-2). |
|
| DC1011 |
Lorcaserin
Featured
|
Lorcaserin (APD-356)is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. |
|
| DC8644 |
Lorcaserin Hydrochloride
Featured
|
Lorcaserin (APD-356)is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. |
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|
| DC8642 |
Lorediplon
Featured
|
Lorediplon is a new GABAA modulator Drug for treatment of insomnia. |
|
| DC8356 |
Losartan Carboxylic Acid
Featured
|
Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver. |
|
| DC9153 |
Losartan Potassium
Featured
|
Losartan is an angiotensin II receptor antagonist, competes with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM. |
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