RTI-7470-44|CAS 825658-63-7|DC Chemicals

Cas No.:	825658-63-7
Chemical Name:	RTI-7470-44
Synonyms:	Acetamide, 2-[[6-(4-chlorophenyl)-3-cyano-4-(trifluoromethyl)-2-pyridinyl]thio]-N-2-pyrimidinyl-;RTI-7470-44;2-((6-(4-Chlorophenyl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl)thio)-N-(pyrimidin-2-yl)acetamide;2-[6-(4-chlorophenyl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-pyrimidin-2-ylacetamide;825658-63-7;RTI747044;DA-67315;SR-03000003639-1;HY-147319;GLXC-25504;CS-0565764;SR-03000003639;MS-28154
SMILES:	C(NC1=NC=CC=N1)(=O)CSC1=NC(C2=CC=C(Cl)C=C2)=CC(C(F)(F)F)=C1C#N
Formula:	C₁₉H₁₁ClF₃N₅Os
M.Wt:	449.84
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC70747	RTI-7470-44	RTI-7470-44 is a highly potent and selective antagonist of the human trace amine-associated receptor 1 (hTAAR1), demonstrating an IC50 of 8.4 nM in an in vitro cAMP functional assay. In radioligand binding studies, it exhibits a Ki value of 0.3 nM, highlighting its strong affinity for hTAAR1. Notably, RTI-7470-44 shows significant species selectivity, with over 90-fold preference for hTAAR1 compared to its rat and mouse counterparts. This compound also possesses favorable pharmacokinetic properties, including good blood-brain barrier penetration, moderate metabolic stability, and a promising off-target safety profile. In electrophysiological studies, RTI-7470-44 enhanced the spontaneous firing rate of dopaminergic neurons in the mouse ventral tegmental area (VTA) and effectively counteracted the effects of the TAAR1 agonist RO5166017.