AM-1638|AM1638;AM 1638;AMG-1638

Cas No.:	1142214-62-7
Chemical Name:	(S)-3-cyclopropyl-3-(3-((2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)phenyl)propanoic acid
Synonyms:	AM1638;AM 1638;AMG-1638
SMILES:	C(O)(=O)C[C@H](C1CC1)C1=CC=CC(OCC2=CC=C(C3=CC(OC)=CC=C3F)C(C3C(C)(C)CCC=3)=C2)=C1
Formula:	C₃₃H₃₅FO₄
M.Wt:	514.637
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM; stimulates GLP-1 and GIP secretion from intestinal enteroendocrine cells and increase GSIS from pancreatic islets, enhances glucose control in mouse models of type 2 diabetes.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC9458	GW-1100	GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
DC11143	GPR40 AgoPAM AP5	GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
DC11623	GPR120 agonist 4x	A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.
DC11680	LY3104607	A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
DC11682	LY2922083	A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
DC11683	LY2881835	A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
DC11697	AM-1638	A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.
DC11994	ZQ-16	A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.