ZQ-16|ZQ 16;ZQ16

Cas No.:	376616-73-8
Chemical Name:	2-(hexylthio)pyrimidine-4,6-diol
Synonyms:	ZQ 16;ZQ16
SMILES:	C(SCCCCCC)1=NC(O)=CC(O)=N1
Formula:	C₁₀H₁₆N₂O₂S
M.Wt:	228.311241149902
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC9458	GW-1100	GW 1100 is a selective antagonist of GPR40-mediated Ca2+ elevations in HEK293 cells stimulated by GW 9508 (an agonist of both GPR40 and GPR120, another GPCR activated by long chain fatty acids) or linoleic acid with a pIC50 value equal to 5.99.
DC11143	GPR40 AgoPAM AP5	GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
DC11623	GPR120 agonist 4x	A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.
DC11680	LY3104607	A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
DC11682	LY2922083	A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
DC11683	LY2881835	A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
DC11697	AM-1638	A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.
DC11994	ZQ-16	A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.