LY2922083

  Cat. No.:  DC11682  
Chemical Structure
1309435-78-6
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
Cas No.: 1309435-78-6
Chemical Name: (S)-3-(4-((5-((2,3-dihydrospiro[indene-1,4'-piperidin]-1'-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid
Synonyms: LY 2922083;LY-2922083
SMILES: C(O)(=O)C[C@H](C1=CC=C(OCC2SC(CN3CCC(CC3)3C4=C(C=CC=C4)CC3)=CC=2)C=C1)C#CC
Formula: C31H33NO3S
M.Wt: 499.669
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, selective, orally available GPR40 agonist with EC50 of 9 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC11143 GPR40 AgoPAM AP5 GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM).
DC11623 GPR120 agonist 4x A potent, selective, orally bioavailable GPR120 agonist with EC50 of 42 nM in calcium flux assays.
DC11680 LY3104607 A potent, selective, orally available GPR40 agonist with Ki of 15 nM, β-arrestin EC50 of 108 nM.
DC11682 LY2922083 A potent, selective, orally available GPR40 agonist with EC50 of 9 nM.
DC11683 LY2881835 A potent, selective, orally available GPR40 agonist with EC50 of 8 nM.
DC11697 AM-1638 A potent, orally bioavailable, full agonist of GPR40/FFA1 with EC50 of 0.16 uM.
DC11994 ZQ-16 A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.
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