| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10069 | CFI-400437 Featured | CFI-400437 is potent against PLK4 (IC50 = 0.6 nM) and selective against other members of the PLK family (>10 uM). |
|
| DC23338 | CFI-401980 | CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM. |
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| DC9340 | CFM-2 | CFM-2 is a selective non-competitive AMPAR antagonist. |
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| DC11133 | CFM-4.16 | CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis. |
|
| DC22809 | c-FMS-IN-8 Featured | c-FMS-IN-8 is a potent, selective c-FMS kinase inhibitor with IC50 of 0.8 nM, shows activity in collagen-induced model of arthritis in mice.. |
|
| DC7039 | CFTR Inhibitor II Featured | CFTR Inhibitor II is a cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells. |
|
| DC12580 | CG-806 Featured | CG-806 (CG806, CG'806) is a novel potent, pan-FLT3/BTK multi-kinase inhibitor with impressive inhibition of leukemic cell proliferation with IC50 at sub-nanomolar or low nanomolar levels. |
|
| DC7380 | CGI-1746 Featured | CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation. |
|
| DC7101 | CGK733 Featured | CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM. |
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| DC10843 | CGP 52432 Featured | CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM). |
|
| DC7381 | CGP-57380 Featured | CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 (IC50 = 2.2 μM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. |
|
| DC10722 | CGP-71683A Featured | CGP 71683A is a potent and highly selective non-peptide antagonist of the NPY Y(5) receptor in the study of obesity. |
|
| DC9849 | CGP37849 | CGP37849 is a potent, selective and competitive NMDA receptor antagonist (Ki = 35 nM). Anticonvulsive following oral administration in vivo. |
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| DC23919 | CGP-42112 Featured | CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM. |
|
| DC23830 | CGP-53353 | CGP-53353 (DAPH-7) is a selective inhibitor of PKCβII with IC50 of 0.41 uM, shows weak activity on PKCβI with IC50 of 3.8 uM. |
|
| DC20887 | CGP-74514A hydrochloride | CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM. |
|
| DC8471 | CGS 21680 hydrochloride Featured | CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM). |
|
| DC24112 | CGS 21680 | CGS 21680 is a specific adenosine A2A subtype receptor agonist with Ki of 27 nM. |
|
| DC21331 | CGS 27023A | CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9. |
|
| DC7939 | CH-223191 Featured | CH-223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. |
|
| DC10974 | Ch-319 | Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer. |
|
| DC7102 | CH5132799 Featured | CH5132799 selectively inhibits class I PI3Ks, such as PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ with IC50 values of 0.014, 0.12, 0.50, and 0.36 uM, respectively; shows less inhibition of class II PI3Ks, class III PI3ks, and mTOR. |
|
| DC8418 | CH5183284 (Debio-1347) Featured | CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1. |
|
| DC7383 | CH5424802(Alectinib) Featured | CH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
|
| DC8728 | CH5424802(Alectinib HCl) Featured | CH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
|
| DC22054 | CH5447240 Featured | CH5447240 is a novel potent, selective, orally active hPTHR1 agonist with EC20 of 3.0 nM and EC50 of 12 nM. |
|
| DC12415 | CH7057288 Featured | CH7057288 (CH-7057288) is a novel potent and selective pan-TRK inhibitor with IC50 of 1.1/7.8/5.1 nM for TRKA/TRKB/TRKC, respectively. |
|
| DC20337 | Chaetocin | Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9. |
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| DC5135 | Chaetominine | Chaetominine , an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium sp. |
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| DC12545 | CHDI-390576 Featured | CHDI-390576 (CHDI390576) is a potent, cell permeable and CNS penetrant class IIa HDAC inhibitor with IC50 of 54/60/31/50 nM for HDAC4/5/7/9, respectively. |
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