| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC12659 | A-381393 Featured | A-381393 is a potent and selective agonist of the dopamine D4 receptor. |
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| DC10129 | A395 Featured | A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7) |
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| DC20610 | A-395N | A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.. |
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| DC22277 | A-420983 Featured | A-420983 is a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. |
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| DC20611 | A4250 Featured | A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH.. |
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| DC8406 | A-438079 HCl Featured | A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. |
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| DC12317 | A-484954 | A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM. |
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| DC7538 | A66 Featured | A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms. |
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| DC5163 | A-674563 Featured | A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. |
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| DC20612 | A-68930 hydrochloride | A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM. |
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| DC7351 | A-740003 | A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
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| DC7045 | A-769662 Featured | A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
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| DC11372 | A-779 Featured | A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay). |
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| DC7785 | A-790742 | A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. |
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| DC20613 | A-800141 | A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM). |
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| DC2061 | A-803467 Featured | A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
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| DC9954 | A 804598 Featured | A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
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| DC7286 | A83-01 Featured | A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). |
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| DC20614 | A-832234 | A-832234 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 19 nM.. |
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| DC23183 | A-836339 | A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively. |
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| DC9516 | A-867744 | A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
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| DC11304 | A939572 Featured | A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. |
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| DC22721 | A-943931 dihydrochloride | A-943931 dihydrochloride is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
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| DC22720 | A-943931 | A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
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| DC7046 | A-966492 Featured | A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
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| DC20616 | AA 41612 Featured | AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner. |
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| DC23202 | JNJ-16259685 | aA highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM. |
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| DC23277 | AA-115 Featured | AA-115 (APG 115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM. |
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| DC21979 | ATF6 agonist compound A147 Featured | ATF6 agonist compound A147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells.147 has broad antiviral activity against multiple DENV strains and serotypes and that the compound i |
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| DC10165 | AA26-9 Featured | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. |
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