| DC20973 |
DS86760016 |
DS86760016 is a novel selective bacterial leucyl-tRNA synthetase (LeuRS) inhibitor with IC50 of 0.38 uM (Escherichia coli, LeuRS). |
|
| DC22081 |
DS88790512 hydrochloride |
DS88790512 is a potent, selective, and orally bioavailable blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).. |
|
| DC22080 |
DS88790512 |
DS88790512 is a potent, selective, and orally bioavailable blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM).. |
|
| DC12193 |
Ds-HAPP |
Ds-HAPP is an anthrancenyl and dansyl fluorophore ligand. |
|
| DC12643 |
DSP-0565 |
DSP-0565 (DSP0565) is a new drug candidate with broad anti-convulsant activity, does not bind to any GABA-A binding sites, may be caused as the result of its GABAergic function via novel target.. |
|
| DC20977 |
DSP-1053 |
DSP-1053 is a novel potent serotonin reuptake (SERT) inhibitor with 5-HT1A partial agonistic activity that binds to human serotonin transporter and 5-HT1A receptor with Ki of 1.02 and 5.05 nM, respectively. |
|
| DC20979 |
DSP-6952 hydrobromide |
DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c. |
|
| DC20980 |
DT204 |
DT204 (DT-204) is a novel SCFSkp2 inhibitor that reduces Skp2 binding to Cullin-1 and Commd1, synergistically enhances BTZ-induced apoptosis. |
|
| DC20367 |
dTRIM24
Featured
|
dTRIM24 is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement). |
|
| DC12473 |
Dual BRM and BRG1 inhibitor 14 |
Dual BRM and BRG1 inhibitor 14 is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both. |
|
| DC11175 |
Dual DDR1 and DDR2 inhibitor 5n
Featured
|
Dual DDR1 and DDR2 inhibitor 5n is a highly potent and selective small molecule inhibitor targeting both Discoidin Domain Receptor 1 (DDR1) and Discoidin Domain Receptor 2 (DDR2). These receptors are receptor tyrosine kinases (RTKs) that play critical roles in cell proliferation, migration, and extracellular matrix (ECM) remodeling. Dysregulation of DDR1 and DDR2 has been implicated in various diseases, including cancer, fibrosis, and inflammation, making them attractive therapeutic targets. |
|
| DC3149 |
Duloxetine hydrochloride |
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). |
|
| DC12054 |
Duocarmycin TM |
Duocarmycin TM is an exceptionally potent antitumor antibiotic. |
|
| DC20368 |
Dynarrestin
Featured
|
Dynarrestin is a novel inhibitor of cytoplasmic Dyneins 1 and 2, acts reversibly to inhibit cytoplasmic dynein 1-dependent microtubule binding and motility in vitro without affecting ATP hydrolysis. |
|
| DC20905 |
Dynein2-IN-37 |
Dynein2-IN-37 (Ciliobrevin analog 37) is a potent, selective cytoplasmic dynein 2 ATPase activity antagonist with IC50 of 11 uM, shows weak inhibition for dynein 2 (IC50=280 uM). |
|
| DC20369 |
Dynole 34-2 |
Dynole 34-2 is a potent dynamin GTPase inhibitor with IC50 of 6.9 and 14.2 uM for full-length dynI and dynII GTPase activity, respectively. |
|
| DC10953 |
DZ-2384 |
DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types. |
|
| DC20985 |
E 6201 |
E 6201 (E6201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM. |
|
| DC20986 |
E 6446
Featured
|
E 6446 is a novel orally available small molecule inhibitor of TLR7 and TLR9 with IC50 of 1.78 uM and 0.01 uM, respectively. |
|
| DC11213 |
E1231
Featured
|
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα). |
|
| DC20370 |
E3 Ligand-Linker Conjugate 1 |
E3 Ligand-Linker Conjugate 1 is an E3 ligand- Linker Conjugate for PROTAC. |
|
| DC11570 |
E3 Ligand-Linker Conjugate 5 |
E3 Ligand-Linker Conjugate 5 is an E3 ligase ligand-linker conjugate for PROTAC.. |
|
| DC12249 |
E3 ligase Ligand 1 dihydrochloride |
E3 ligase Ligand 1 dihydrochloride is a Hippel-Landau (VHL) E3 ligase-binding moiety based on PROTAC technology. |
|
| DC11565 |
E3 Ligase Ligand 2
Featured
|
E3 ligase Ligand 2 is a Ligand for E3 Ligase used in PROTAC technology. |
|
| DC12092 |
E3 Ligase Ligand-Linker Conjugates 23 TFA |
E3 Ligase Ligand-Linker Conjugates 23 (TFA) is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC12181 |
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate |
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology. |
|
| DC7128 |
Lucitanib(E3810)
Featured
|
E-3810 is a novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. |
|
| DC9595 |
E-4031
Featured
|
E-4031 is a benzenesulfonamide antiarrhythmic agent; blocks the ATP-sensitive potassium channel.
|
|
| DC8533 |
E5555 hydrobromide |
E5555 shows potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC values of 0.064 and 0.031 μM respectively. |
|
| DC23442 |
E-5842 |
E-5842 is a preferential sigma-1 receptor ligand, demonstrates potential atypical antipsychotic effects in vivo. |
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