| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11842 | BI 135585 | BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
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| DC22020 | BI-1388 | BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K. |
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| DC20777 | BI-1935 | BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM. |
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| DC22022 | BI-1950 | BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM. |
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| DC11602 | BI-2545 | BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively. |
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| DC22023 | BI-3663 | BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines. |
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| DC20779 | BI-3802 Featured | BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
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| DC22024 | BI-4394 | BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM). |
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| DC11960 | BI605906 Featured | BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
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| DC20784 | BI8622 | BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b). |
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| DC20785 | BI8626 | BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM). |
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| DC23608 | BI-9627 | BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. |
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| DC12567 | BI-9667 | BI-9667 (BI9667) is a potent, selective CCR1 antagonist.. |
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| DC22027 | BI-99179 | BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM. |
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| DC10404 | BIA 10-2474 Featured | BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
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| DC4206 | Biapenem | Biapenem is a carbapenem antibiotic. |
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| DC23366 | biBET | biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively. |
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| DC20788 | BIBO-3304 Featured | BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively. |
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| DC12211 | BIBR 1087 SE (Desethyl Dabigatran Etexilate) | BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate. |
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| DC7085 | BIBR-1532 Featured | BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM. |
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| DC20789 | BIBU1361 | BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
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| DC20790 | BIBU1361 dihydrochloride | BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM). |
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| DC10393 | Bicyclomycin benzoate | Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium. |
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| DC20791 | BIIL260 | BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM. |
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| DC20793 | BILH-434 | BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay.. |
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| DC20795 | BIO 8898 | BIO 8898 is a synthetic, CD40-CD154 co-stimulatory interaction inhibitor that inhibits the TNF family cytokine CD40L binding to CD40-Ig with a potency of IC50=25 uM. |
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| DC11178 | BIO1211 | BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1. |
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| DC11069 | BIO124 | BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1.. |
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| DC12401 | BIO922 | BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors. |
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| DC20320 | Bio-AMS | Bio-AMS is a chemical inhibitor of Mycobacterium tuberculosis biotin protein ligase ( MtBPL) with Kd of 0.865 nM. |
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