| DC11498 |
FOXO1-IN-8 |
A small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes. |
|
| DC11517 |
Benzodrocortisone |
A synthetic glucocorticoid corticosteroid.. |
|
| DC12317 |
A-484954 |
A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM. |
|
| DC11149 |
AC261066 |
AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
|
| DC7354 |
Acolbifene |
acolbifene, also known as EM-652, or SCH-57068, is a selective estrogen receptor modulator (SERM). Acolbifene is currently being studied in the prevention of breast cancer in women at high risk of breast cancer. EM-652 (SCH 57068) and the prodrug EM-800 ( |
|
| DC10812 |
ACP-105
Featured
|
ACP-105 is a novel non-steroidal SARM (Selective Androgen Receptor Modulator). |
|
| DC8122 |
Andarine (GTX-007,S-4)
Featured
|
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity. |
|
| DC8664 |
APTO-253 |
APTO-253 is a novel small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |
|
| DC7358 |
APY29
Featured
|
APY29 is an allosteric modulator of IRE1α; inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity. |
|
| DC10135 |
AR-7
Featured
|
AR7 is a retinoic acid receptor α (RARα) antagonist. |
|
| DC7064 |
Apalutamide（ARN509）
Featured
|
ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. |
|
| DC10086 |
AS1842856
Featured
|
AS1842856 is a potent and cell-permeable Foxo1 inhibitor with an IC50 of 30 nM. |
|
| DC4169 |
ASC-J9 |
ASC-J9, is antitumor agent. ASC-J9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors. |
|
| DC5013 |
AZD3514 |
AZD3514 is a potent and oral androgen receptor with Ki of 2.2 μM and has ability of reducing AR protein expression. |
|
| DC9268 |
AZD9496
Featured
|
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator(Ki=0.7 nM) and antagonist. |
|
| DC11541 |
AZD-9567 |
AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.. |
|
| DC11542 |
AZD-9567 monohydrate |
AZD-9567 (AZD9567) is a potent, selective, non-steroidal and orally available selective glucocorticoid receptor modulator (SGRM) for treatment of rheumatoid arthritis.. |
|
| DC11032 |
AZD9977
Featured
|
AZD9977 is a first-in-class, potent, selective, mineralocorticoid receptor (MR) modulator with IC50 of 0.37. 0.08 and 0.08 uM for human, mouse and rat MR, respectively. |
|
| DC4135 |
Bardoxolone methyl
Featured
|
Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. |
|
| DC7372 |
Bazedoxifene-Acetate
Featured
|
Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. |
|
| DC8922 |
Bazedoxifene
Featured
|
Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment. |
|
| DC9088 |
Bezafibrate |
Bezafibrate(BM15075) is the first clinically tested dual and pan-PPAR co-agonism. |
|
| DC9252 |
BMS-687453
Featured
|
BMS687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) α agonist, with an EC50 of 10 nM for human PPARα and ∼410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays. |
|
| DC9861 |
BMS-779788(XL-652)
Featured
|
BMS-779788(XL652) is a novel small-molecule modulator of the Liver X Receptor (LXR), a nuclear hormone receptor implicated in a variety of cardiovascular and metabolic disorders. |
|
| DC9547 |
Boldenone Undecylenate |
Boldenone undecylenate(Equipoise) is a synthetic steroid which has a similar effect as the natural steroid testosterone; it is frequently used in veterinary medicine, though it is also used in humans.
|
|
| DC11499 |
BPK-29 |
BPK-29 is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells. |
|
| DC10913 |
Brusatol |
Brusatol (NSC 172924, (+)-Brusatol) is a quassinoid extracted from Brucea Esters, can inhibit HIF-1 signaling pathway, also is a potent Nrf2 inhibitor. |
|
| DC11493 |
C2BA-4 |
C2BA-4(C2BA 4) is a potent, specific human Pregnane X receptor (hPXR) activator with EC50 of 49 nM. |
|
| DCAPI1559 |
Calcifediol
Featured
|
Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
|
| DCAPI1415 |
Calcipotriol(Calcipotriene)
Featured
|
Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor. |
|
