| DC9821 |
Ezutromid
Featured
|
Ezutromid is a novel Small utrophin's translation modulator with EC50 of 0.4 uM . |
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| DC8912 |
Fesoterodine fumarate
Featured
|
Fesoterodine Fumarate is an antimuscarinic agent and is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine that is a muscarinic receptor antagonist. |
|
| DC11187 |
Fonadelpar |
Fonadelpar (NPS-005,SJP-0035) is a potent, selective peroxisome proliferator activated receptor δ (PPARδ) agonist for the treatment of corneal disorders.. |
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| DC11394 |
Fulacimstat(BAY 1142524)
Featured
|
Fulacimstat(BAY 1142524) is a small molecule chymase inhibitor. |
|
| DC9859 |
GAL-021
Featured
|
GAL-021 is a new intravenous BKCa-channel blocker. |
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| DC9738 |
GSK2881078
Featured
|
GSK-2881078 is an orally active and nonsteroidal selective androgen receptor modulator (SARM) which act as partial AR agonists in androgenic tissues while mainly as complete AR agonists in synthetic metabolic tissues,induces AR-mediated transcriptional activation in PC3(AR)2 cells (EC50 = 3.99 nM) and the effect can be inhibited by the non-steroidal AR antagonist Bicalutamide. GSK-2881078 can be used in research of muscle weakness and cachexia associated with both chronic and acute illness. |
|
| DC10007 |
Ibiglustat(Genz-682452）
Featured
|
Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
|
| DC7430 |
Obeticholic acid (INT-747)
Featured
|
INT-747(Obeticholic acid; 6-ECDCA) is a potent and selective FXR agonist(EC50=99 nM) endowed with anticholestatic activity. |
|
| DC7172 |
IOWH-032 |
iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. |
|
| DC12374 |
JNJ-10229570
Featured
|
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
|
| DC10853 |
LAU159
Featured
|
LAU159 is a novelα6β3γ2 GABAA receptor inhibitor. |
|
| DC12386 |
Leniolisib (CDZ173)
Featured
|
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor currently in phase II/III clinical trials for the treatment of immunodeficiency disorders. |
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| DC7633 |
Ligandrol (VK5211, LGD-4033)
Featured
|
Ligandrol (LGD-4033) is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of 1 nM) and selectivity. |
|
| DC9938 |
Lusutrombopag（S-888711）
Featured
|
Lusutrombopag（S-888711） is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. |
|
| DC11524 |
Mavacamten（MYK-461）
Featured
|
Mavacamten（MYK-461）is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain. |
|
| DC9527 |
Methylnaltrexone (Bromide)
Featured
|
Methylnaltrexone Bromide is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation.
|
|
| DC10326 |
Mozavaptan |
Mozavaptan (OPC31260) is a orally effective, nonpeptide vasopressin V2 receptor antagonist with an IC50 of 14 nM. |
|
| DCAPI1342 |
Nepafenac |
Nepafenac |
|
| DC12298 |
Octreotide acetate (SMS 201-995 (acetate))
Featured
|
Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. |
|
| DC10299 |
Olumacostat glasaretil |
Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). |
|
| DC11044 |
Omidenepag Isopropyl
Featured
|
Omidenepag Isopropyl (DE-117, OMDI) is the prodrug of Omidenepag, which is a potent, selective agonist human EP2 receptor; demonstrates excellent IOP-lowering activities following ocular administration in ocular normotensive monkeys, Omidenepag Isopropyl (OMDI) is a clinical candidate for the treatment of glaucoma. |
|
| DC8353 |
PF-04418948
Featured
|
PF-04418948 is an orally active, potent, and selective EP2 receptor antagonist (IC50 = 16 nM). |
|
| DCAPI1305 |
Pramiracetam |
Pramiracetam |
|
| DC9162 |
Ranolazine HCl
Featured
|
Ranolazine(RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). |
|
| DC1048 |
Rapamycin (Sirolimus)
Featured
|
Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. - |
|
| DC8185 |
Verosudil(AR-12286) |
Rho-kinase (ROCK) inhibitor |
|
| DC10583 |
RO 5028442
Featured
|
RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a). |
|
| DC8198 |
RTA-408(Omaveloxolone)
Featured
|
RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB. |
|
| DC8224 |
Lifitegrast(SAR 1118)
Featured
|
SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. |
|
| DC10925 |
SAR-100842
Featured
|
SAR-100842 (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
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