Methylnaltrexone (Bromide)

Cas No.:	73232-52-7
Chemical Name:	Methyl naltrexone bromide
Synonyms:	N-Methyl Naltrexone Bromide;Naltrexone methylbromide;(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one,bromide;17-(CYCLOPROPYLMETHYL)-4,5A-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXOMORPHINANIUM BROMIDE;Methylnaltrexone (Bromide);Methylnaltrexone bromide;(-)-naltrexone methyl bromide;[14C]-N-Methylnaltrexone bromide;MNTX;MNTX bromide;MOA-728;MRZ-2663BR;Naltrexone methobromide;Relistor;Relistor (TN);(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide
SMILES:	[Br-].O[C@@]12CCC([C@@]3([H])[C@@]41C1C(=C(C=CC=1C[C@@]2([H])[N@+](C)(CC1CC1)CC4)O)O3)=O
Formula:	C21H26BrNO4
M.Wt:	436.339445590973
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Methylnaltrexone Bromide is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation. Methylnaltrexone is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. Because Methylnaltrexone contains a permanently charged tetravalent nitrogen atom, it cannot cross the blood-brain barrier, and so has antagonist effects throughout the body, counteracting effects such as itching and constipation, but without affecting opioid effects in the brain such as analgesia. However, since a significant fraction (up to 60 %) of opioid analgesia can be mediated by opioid receptors on peripheral sensory neurons, particularly in inflammatory conditions such as arthritis, traumatic or surgical pain, Methylnaltrexone may increase pain under such circumstances.