| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DCC5459 | Vu0453379 | Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM) |
|
| DCC5460 | Vu0462054 | Novel potent and selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM) |
|
| DCC5461 | vu0463841 | Potent and selective mGlu5 negative allosteric modulator (NAM) |
|
| DCC5462 | Vu0477886 | Novel potent mGlu4 PAM with an attractive DMPK profile, and robust efficacy in preclinical Parkinsons disease model, haloperidol-induced catalepsy (HIC) |
|
| DCC5463 | Vu0486321 | mGlu1 positive allosteric modulator (PAM) |
|
| DCC5464 | Vu0487836 | Novel cyclooxygenase-1 (COX-1)-selective inhibitor |
|
| DCC5465 | vu573 Hydrochloride | Novel modulator of mammalian inward rectifying potassium (Kir) channels |
|
| DCC5466 | Vu6001192 | Novel selective negative allosteric modulator (NAM) of metabotropic glutamate receptor subtype 2 |
|
| DCC5467 | Vu6004909 | Novel potent and highly selective mGlu1 PAM (22nM), reducing striatal DA release in vivo and displaying antipsychotic efficacy |
|
| DCC5468 | Vu6007705 | Novel Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) |
|
| DCC5469 | Vu6008555 | Novel Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) |
|
| DCC5470 | Vu6009453 | Novel M4 positive allosteric modulator (PAM) |
|
| DCC5471 | Vu6009833 | Novel CNS penetrant pan-muscarinic antagonist |
|
| DCC5472 | Vu6013429 | Novel PAM of Group III (mGlu4/6/7/8) mGlu receptors |
|
| DCC5473 | Vu6017587 | Novel selective mGlu3 NAM, showing efficacy in tail suspension, elevating zero maze and marble burying, suggesting selective inhibition of mGlu3 affords anxiolytic-like and antidepressant-like phenotypes in mice |
|
| DCC5474 | Vu6027459 | First-in-class selective mGlu7 positive allosteric modulator (PAM), displaying CNS penetration in both mice (Kp = 2.74) and rats (Kp= 4.78) |
|
| DCC5475 | Vuf 5681 Dihydrobromide | Potent histamine H3 receptor silent antagonist |
|
| DCC5476 | Vuf10132 | Novel full inverse agonist at CXCR3 N3.35A |
|
| DCC5477 | vuf10148 | Potent H4R ligand |
|
| DCC5478 | Vuf10166 Hydrochloride | Novel potent ligand at 5-HT3A and 5-HT3AB receptors with different activities |
|
| DCC5479 | Vuf10497 Featured | VUF10497 is a potent histamine H4 receptor (H4R) inverse agonist with anti-inflammatory activity. |
|
| DCC5480 | Vuf10499 | Potent human H4 receptor inverse agonist |
|
| DCC5481 | Vuf10558 | Highly Potent Human Histamine H4 Receptor Inverse Agonist |
|
| DCC5482 | Vuf11211 | Potent CXCR3 Antagonist, extending from the minor pocket into the major pocket of the transmembrane domains and binding between residues in helices 1 (Y1.39), 2 (W2.60), 3 (F3.32), 4 (D4.60), 6 (Y6.51), and 7 (S7.39, Y7.43) |
|
| DCC5483 | Vuf11222 | First reported nonpeptidomimetic agonist on The G protein-coupled chemokine receptor CXCR3 |
|
| DCC5484 | vuf14480 | Partial agonist in hH 4 R-mediated G protein signalling and β-arrestin2 recruitment, bounding covalently to the hH4R |
|
| DCC5485 | Vuf14738 | Novel robust and fatigue-resistant photoswitchable GPCR antagonist |
|
| DCC5486 | Vuf14862 | Novel robust and fatigue-resistant photoswitchable GPCR antagonist |
|
| DCC5487 | Vuf15259 | Novel inhibitor of Hbp secretion, activating σE stress, impairing Hbp secretion and decreasing the abundance of OMPs, consistent with impaired BAM function |
|
| DCC5488 | Vuf15888 | Novel photoswitchable modulator of the CXCR3 chemokine receptor |
|
