| DC40341 |
Ivermectin B1b |
Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture. |
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| DC40362 |
TCMDC-135051 hydrochloride |
TCMDC-135051 hydrochloride is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC50=320 nM). |
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| DC40370 |
Ivermectin B1a
Featured
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Ivermectin B1a, a derivative of Avermectin B1a, is a main component of Ivermectin. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19.
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| DC40376 |
AN7973 |
AN7973 is the 6-carboxamide benzoxaborole, blocks intracellular parasite development and inhibits Cryptosporidium growth. AN7973 is orally active, possesses favorable safety, stability, and PK parameters, and is an exciting drug candidate for treating cryptosporidiosis. |
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| DC40449 |
Isatropolone A |
Isatropolone A, a natural product containing a 1,5-diketone moiety, is reisolated from Streptomyces G?66. Isatropolone A shows potent activity against Leishmania donovani with an IC50 of 0.5 μM. |
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| DC40770 |
Imidocarb dihydrochloride monohydrate |
Imidocarb dihydrochloride monohydrate is a potent antiprotozoal agent. Imidocarb dihydrochloride monohydrate is active against the parasite B. bovis with an IC50 of 87 μg/mL. |
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| DC40946 |
SJ000025081 |
SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with?P. yoelii. |
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| DC40948 |
Triclabendazole sulfoxide |
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP. |
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| DC40952 |
3-ANOT |
3-ANOT is a metabolite of Dinitolmide (a nitroamide coccidiostat commonly used in poultry production). |
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| DC41034 |
Quinacrine hydrochloride hydrate |
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis. |
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| DC41099 |
Chloroquine D5 |
Chloroquine D5 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM). |
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| DC41100 |
Chloroquine dihydrochloride |
Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM). |
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| DC41101 |
Rafoxanide 13C6 |
Rafoxanide 13C6 is a labeled Rafoxanide. Rafoxanide is a salicylanilide used as an antiparasitic agent.
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| DC41128 |
Sitamaquine tosylate |
Sitamaquine (WR 6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes. |
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| DC41178 |
Fenbendazole-d3 |
Fenbendazole-d3 is a deuterium labeled Fenbendazole. Fenbendazole is a benzimidazole anthelmintic. Fenbendazole is active against Giardia in vitro (IC50 = 0.3 μM). Fenbendazole (20 mg/kg) prevents infiltration of parasites into the brain in a rabbit model of E. cuniculi infection. Fenbendazole also activates HIF-1α and prevents oxidative stress-induced death in primary neurons in vitro. |
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| DC41179 |
Sulfadoxine D3 |
Sulfadoxine D3 is a deuterium labeled Sulfadoxine. Sulfadoxine is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells. |
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| DC41193 |
Proguanil hydrochloride |
Proguanil hydrochloride, an antimalarial prodrug, is metabolized to the active metabolite Cycloguanil. Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor.
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| DC41216 |
Dimetridazole-d3 |
Dimetridazole-d3 (1,2-Dimethyl-5-nitroimidazole-d3) is a deuterium labeled Dimetridazole. Dmetridazole, a nitroimidazole-based antibiotic, combats protozoan infections. |
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| DC41221 |
Amodiaquine dihydrochloride |
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect. |
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| DC41243 |
Hexythiazox |
Hexythiazox is a selective acaricide with ovicidal, larvicidal and nymphicidal activities. Hexythiazox is widely used for chemical control of mites on cotton, fruits and vegetables. Hexythiazox is harmless to mammals and has no effect on beneficial insects and predators of mites. |
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| DC41250 |
Fenitrothion |
Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols. |
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| DC41252 |
Thiacloprid |
Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions. |
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| DC41257 |
Propargite |
Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC50?of?1?μM. |
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| DC41268 |
Quinine hemisulfate hydrate |
Quinine hemisulfate hydrate is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine hemisulfate hydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM. |
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| DC41314 |
Thalifendine chloride |
Thalifendine chloride is a metabolite of Berberine, with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activity against P. falciparum and E. histolytica with IC50s of 7.91 μM and 116 μM, respectively.
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| DC41339 |
9-Hydroxycalabaxanthone |
9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM). |
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| DC41422 |
4'-Hydroxy-2,4-dimethoxychalcone |
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity. |
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| DC41447 |
Oxysanguinarine |
Oxysanguinarine (Hydroxysanguinarine;8-Oxosanguinarine) is a protoberberine alkaloid from Meconopsis simplicifolia with antimalarial activity. |
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| DC41450 |
Atherosperminine |
Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC50 of 5.80 μM. Atherosperminine is good reductants with the ability to chelate metals and presented pro-oxidant activity. Atherosperminine exerts a non-specific relaxant effect on the trachealis. |
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| DC42077 |
Melarsonyl dipotassium |
Melarsonyl dipotassium (Melarsonic acid dipotassium) is an anthelmintic agent which can inhibit parasite potently. |
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