| DC74417 |
GTX-134 |
GTx-134 (GTx 134) is a selective small-molecule inhibitor of IGF-1R and insulin receptor (IR) with biochemical IC50 of 97 nM and 187 nM, respectively. |
|
| DC74418 |
GNE-4997 |
GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (ITK) with Ki of 0.09 nM. |
|
| DC74419 |
JTE-051 |
JTE-051 (JTE051) is a potent, selective inhibitor of interleukin-2-inducible T cell kinase (ITK), suppresses overactive immune response via inhibition of the signal to activate T cells related to immune response. |
|
| DC74420 |
HSN608 |
HSN608 (HSN 608) is a potent inhibitor of RET solvent-front mutants, inhibits RET G810 solvent-front mutants and the V804M gatekeeper mutant with IC50 of <50 nM in cell culture, inhibits ABL1(T315I) with IC50 of 40.7 nM. |
|
| DC74421 |
TG 100801 |
The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family. |
|
| DC74422 |
BI 1342561 |
BI 1342561 is a novel potent and selective SYK inhibitor developed to treat severe asthma. |
|
| DC74423 |
BI 894416 |
BI 894416 is a novel potent and selective SYK inhibitor developed to treat severe asthma. |
|
| DC74424 |
MRL-SYKi |
MRL-SYKi is a potent, selective inhibitor of Syk (Spleen tyrosine kinase) with IC50 of <100 nM, also potently inhibits ZAP70 (24 nM in vitro). |
|
| DC74425 |
MTX-216 |
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM. |
|
| DC74426 |
RDN009 |
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM. |
|
| DC74427 |
RDN2150 |
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70. |
|
| DC74428 |
Adrixetinib |
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
|
| DC74429 |
ER-851 |
ER851 (ER-851) is a potent and highly selective AXL inhibitor. |
|
| DC74430 |
INCB081776 |
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
|
| DC74431 |
R992 |
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
|
| DC74432 |
UNC2025 hydrochloride |
UNC2025 is a potent, orally bioavailable Mer/FLT3 dual inhibitor with IC50 of 0.74/0.8 nM, 700-fold less active against Met compared to Mer. |
|
| DC74433 |
Anizatrectinib |
Anizatrectinib is a potent and orally active inhibitor of TrkA kinase with potential for inflammatory disease such as prostatitis. |
|
| DC74434 |
Emzeltrectinib |
Emzeltrectinib is a potent, selective neurotrophic factor tyrosine kinase receptor TrkB inhibitor, shows potential for treatment of Trk kinase-mediated tumor. |
|
| DC74435 |
PTX-BD10-2 |
PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity. |
|
| DC74436 |
COB223 |
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM. |
|
| DC74437 |
NRP1-4 |
NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A. |
|
| DC74438 |
NRPa-308
Featured
|
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity. |
|
| DC74439 |
SYHA1813 |
SYHA1813 is a potent dual inhibitor of CSF1R and VEGFR with IC50 of 19.3, 2.8, 0.3, and 4.3 nM for CSF1R, VEGFR1, 2, and 3, respectively. |
|
| DC74440 |
CW85319 |
CW85319 is a small-molecule compound that enhances Axin2's interaction with GSK3β, shows a high-affinity binding with Axin2 with Kd of 5.8 uM. |
|
| DC74441 |
iCRT-3 |
iCRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM. |
|
| DC74442 |
IMU1003 |
IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation. |
|
| DC74443 |
AB668 |
AB668 is a selective, bivalent Casein Kinase 2 (CK2) inhibitor targeting the ATP site and the αD pocket, AB668 inhibits the CK2 holoenzyme with Ki value of 41 nM (IC50=65 nM). |
|
| DC74444 |
CKR-49-17 |
CKR-49-17 is a potent, allosteric small molecule activator of CK1γ2 with Kd value of 180 nM in MST assays. |
|
| DC74445 |
FL-1607
Featured
|
FL-1607, a novel Fam20C inhibitor, has shown remarkable anti-proliferative effects in triple-negative breast cancer (TNBC) cells. This compound induces apoptosis and significantly reduces the migration ability of MDA-MB-468 cells, underscoring its potential as a promising therapeutic agent for TNBC treatment. |
|
| DC74447 |
SGC-CK2-1 analog 2h |
SGC-CK2-1 analog 2h is potent, selective and in vivo active inhibitor of casein kinase 2α (CSNK2A, CK2α) with pIC50 of 7.5 and 7.7 against CSNK2A1 and CSNK2A2, respectively. |
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