DC9675 |
Pardoprunox.HCl(SLV-308)
Featured
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Pardoprunox hydrochloride is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
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DC6911 |
pardoprunox (SLV308)
Featured
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Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%, respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA |
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DC10255 |
Parecoxib |
Parecoxib is a selective COX2 inhibitor. |
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DCAPI1503 |
PARECOXIB SODIUM |
PARECOXIB SODIUM |
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DC10604 |
PARGYLINE HYDROCHLORIDE
Featured
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Pargyline is an irreversible inhibitor of monoamine oxidase (MAO; Kis = 15 and 1.8 μM for MAO-A and MAO-B, respectively). |
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DC6577 |
Paricalcitol |
Paricalcitol |
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DC10893 |
Parimifasor
Featured
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Parimifasor is an immunomodulator, with anti-inflammatory activity. |
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DC9098 |
Paroxetine HCl
Featured
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Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). |
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DC21935 |
PARP10 inhibitor 22 |
PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members. |
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DC12450 |
PARP11 inhibitor ITK7 |
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs. |
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DC21104 |
PARP14 inhibitor H10 |
PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively). |
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DC11445 |
Parthenolide
Featured
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Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). |
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DC11992 |
PAT-048 |
PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX. |
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DC21456 |
PAT-1251 |
PAT-1251 (PAT 1251, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases. |
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DC11991 |
PAT-505 |
PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX. |
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DC12184 |
Paullinic acid |
Paullinic acid is a long-chain fatty acid that has been detected in multiple biofluids, such as blood and urine. |
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DC9865 |
Paulownin
Featured
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Paulownin can highly inhibit the growth of H. pylori and exhibits strong inhibitory specificity against H. pylori related to E. coli. |
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DC21457 |
Pax2 inhibitor EG1
Featured
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Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM; inhibits Pax2 mediated expression with IC50 of 10 uM, and inhibits proliferation of Pax2 positive renal and ovarian cancer cell lines but has little effect on Pax2 negative cancer cells; inhibits embryonic kidney development. |
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DC9776 |
Pazopanib Hydrochloride
Featured
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Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. |
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DC2600 |
Pazopanib
Featured
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Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR-α/β, and c-Kit. |
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DC10157 |
PAβN dihydrochloride
Featured
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PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. |
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DC22190 |
PBF509 |
PBF509 (PBF-509, NIR 178) is a novel selective and potent Adenosine A2A Receptor (A2AR) antagonist, antagonizes A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 and 8.2 nM, respectively. |
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DC11100 |
PBI-4050 sodium |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
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DC11099 |
PBI-4050 |
PBI-4050 (Setogepram, PBI4050) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively. |
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DC7550 |
PBIT
Featured
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PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. |
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DC22191 |
PBT434
Featured
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PBT434 is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease; inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology; prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD. |
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DC9723 |
PBTZ169
Featured
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PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor. |
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DC21459 |
PC1244 |
PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM. |
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DC11770 |
PC786
Featured
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PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively. |
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DC21460 |
PC945 |
PC945 is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively. |
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