DC21936 |
PD1-PD L1 inhibitor Polaris |
PD1-PD L1 inhibitor Polaris is a novel potent, small molecule inhibitor of PD-1/PD-L1 interaction (IC50=0.1-10 nM in ELISA assays) with anti-cancer activity. |
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DC8744 |
PD318088
Featured
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PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
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DC21467 |
PDD 00017273
Featured
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PDD 00017273 is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM. |
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DC23693 |
PDE10A-IN-31 |
PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A. |
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DC23701 |
PDE10A-IN-32 |
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM).. |
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DC10345 |
PDE1-IN-2 |
PDE1-IN-2 is an inhibitor of PDE1 extracted from patent WO2016/55618 A1, example 31; has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. |
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DC12555 |
PDE2 inhibitor 4 |
PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms. |
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DC23698 |
PDE4D-IN-26b |
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
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DC23807 |
PDEδ-IN-99 |
PDEδ-IN-99 is a novel potent K-Ras-PDEδ inhibitor that binds to the farnesyl binding pocket of PDEδ with Kd of 8±4 nM.. |
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DC20047 |
PDGFRα kinase inhibitor 1 |
PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively. |
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DC9587 |
PDK1 inhibitor |
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.. |
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DC10904 |
PDM2
Featured
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PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. |
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DC8168 |
Peficitinib(ASP015K,JNJ-54781532)
Featured
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Peficitinib(ASP015K,JNJ-54781532) is a novel potent JAK inhibitor, which demonstrated potent efficacy in adjuvant-induced arthritis model in rats. |
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DCAPI1314 |
Pefloxacin mesylate |
Pefloxacin mesylate |
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DC7225 |
Pelitinib (EKB-569; WAY-EKB 569)
Featured
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Pelitinib (EKB-569; WAY-EKB 569) is a potent irreversible EGFR inhibitor with IC50 of 38.5 nM. |
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DC11360 |
Pemafibrate
Featured
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Pemafibrate is an orally bioavailable and selective agonist of peroxisome proliferator-activated receptor α (PPARα; EC50 = 1 nM for transcriptional activity), a transcription factor that is essential for regulation of lipid homeostasis. |
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DCAPI1528 |
Pemetrexed Disodium Hemipentahydrate
Featured
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Pemetrexed Disodium Hemipentahydrate |
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DC8149 |
Pemetrexed disodium
Featured
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Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
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DC12178 |
Pemigatinib
Featured
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Pemigatinib is a selective FGFR inhibitor in development for the treatment of patients with cholangiocarcinoma. |
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DC9018 |
Pemirolast potassium |
Pemirolast Potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. |
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DCAPI1224 |
Penicillamine (Cuprimine) |
Penicillamine (Cuprimine) |
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DC10507 |
Pentamidine dihydrochloride
Featured
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Pentamidine Dihydrochloride(MP601205 dihydrochloride) is an antimicrobial agent. |
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DC12203 |
Pentanoic acid |
Pentanoic acid, a short-chain fatty acid, is a product of bacterial metabolism and are associated with allergic skin disorders. Pentanoic acid activates ROCK signaling pathway. |
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DC7041 |
Pentostatin(Deoxycoformycin)
Featured
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Pentostatin(Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). |
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DC12194 |
PEO-IAA
Featured
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PEO-IAA is an indole-3-acetic acid (IAA) antagonist. PEO-IAA is an auxin antagonist that binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). |
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DC7989 |
PEPA
Featured
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PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. |
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DC12301 |
Pepstatin Ammonium (Pepstatin A Ammonium) |
Pepstatin Ammonium is a specific aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and he |
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DC20494 |
Peptide Fz7-21 |
Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM. |
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DC21021 |
Peptide P60
Featured
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Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection. |
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DCAPI1121 |
Peramivir |
Peramivir |
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