DC12585 |
TB47
Featured
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QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates. |
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DC21549 |
QD 232 |
QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration. |
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DC21550 |
QD 325 |
QD325 is a potent redox modulator that induces Nrf2-mediated oxidative stress and unfolded protein responses in PDAC cells (IC50=0.9 uM). |
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DC7747 |
QL-IX-55 |
QL-IX-55 is a selective ATP-competitive inhibitor of mTORC1/2 with IC50s of 50/50/10-50 nM for Human mTORC1/Yeast mTORC1/Yeast mTORC2, respectively |
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DC20522 |
QL-X-138 |
QL-X-138 is a selective and potent BTK/MNK dual kinase inhibitor with IC50 of 8, 107.4, and 26 nM for BTK, MNK1, and MNK2, respectively. |
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DC12556 |
QM31 |
QM31 (SVT016426, Apaf-1 inhibitor QM31) is a cytoprotective agent that inhibits the formation of the apoptosome (IC50=7.9 uM in vitro), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. |
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DC11478 |
QM385 |
QM385 is a highly potent small molecule SPR inhibitor,that inhibits the BH4 pathway, blocking T cell proliferation and autoimmunity. |
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DC8307 |
QNZ46
Featured
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QNZ is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). |
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DC12605 |
QO IIR |
QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM. |
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DC5139 |
QS 11 (QS11,BML-WN117) |
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. |
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DC11160 |
Qstatin
Featured
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QStatin is a novel, potent, and selective Vibrio quorum sensing (QS) inhibitor, shows pan-QS inhibitor activity in diverse Vibrio species. |
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DC22204 |
QTX125 |
QTX125 (QTX-125) is a novel potent, selective HDAC6 inhibitor, displays excellent selectivity over other HDACs. |
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DC7664 |
Quarfloxin (CX-3543)
Featured
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Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. |
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DCAPI1284 |
Quercetin dihydrate (Sophoretin) |
Quercetin dihydrate (Sophoretin) |
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DC26061 |
Questiomycin A
Featured
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Questiomycin A is a phenoxazine and a chromophore that has been found in Streptomyces and has antibacterial and anticancer activities. |
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DC9192 |
Quetiapine Fumarate
Featured
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Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. |
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DC8691 |
Quetiapine sulfoxide dihydrochloride |
Quetiapine Sulfoxide is a metabolite of Quetiapine. Quetiapine is an atypical antipsychotic approved for the treatment of schizophrenia, bipolar disorder, and along with an antidepressant to treat major depressive disorder. |
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DC9916 |
Quillaic acid(Quillaja sapogenin)
Featured
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Quillaic acid(Quillaja sapogenin) is the major aglycone of the widely studied saponins of the Chilean indigenous tree Quillaja saponaria Mol; can elicit dose-dependent antinociceptive effects in two murine thermal models. |
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DC20523 |
Quinalizarin |
Quinalizarin is a potent, selective and cell-permeable inhibitor of CK2 with Ki of 58 nM. |
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DCAPI1281 |
Quinine HCl dihydrate |
Quinine HCl dihydrate |
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DC12365 |
Quinupristin
Featured
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Quinupristin/dalfopristin, or quinupristin-dalfopristin is a combination of two antibiotics used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. |
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DC7176 |
Quisinostat (JNJ-26481585) 2HCl
Featured
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Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11. |
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DC24047 |
Quizartinib hydrochloride
Featured
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Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
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DC5197 |
Quizartinib (AC220)
Featured
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Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 1/2. |
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DC9283 |
Q-VD-Oph
Featured
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Q-VD-Oph is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1,3,8, and 9. |
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DC10902 |
QX-77
Featured
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QX77 is a chaperone-mediated autophagy (CMA) activator. |
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DC8657 |
R112
Featured
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R112 is an ATP-competitive inhibitor of Syk kinase with a Ki of 96 nM. R112 inhibits Syk kinase activity with an IC50 of 226 nM. |
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DC10401 |
R121919
Featured
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R121919 is a potent small-molecule CRF1 receptor antagonist with a Ki of 2 to 5 nM for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types. |
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DC10053 |
R1487
Featured
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R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis. |
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DC7322 |
R1487 Hydrochloride
Featured
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R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis. |
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