| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22932 | TLR7-Agonist-54 | A potent TLR7 agonist with EC50 of 8.6 nM. . |
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| DC22934 | 3M-011 Featured | 3M-011 is a potent TLR7/8 agonist and cytokine inducer; stimulates type I interferon (IFN) and other cytokines such as TNF-alpha, IL-12, and IFN-gamma from rat peripheral blood mononuclear cells; induces IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals, and inhibits H3N2 influenza viral replication in the nasal cavity; potentiates NK cytotoxicity, and shows antitumor effects in scid/B6 mice and scid/NOD mice. |
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| DC22922 | 3M-003 Featured | A potent TLR7/8 agonist that induces robust production of the Th1-polarizing cytokines TNF-alpha and IL-12 from neonatal antigen-presenting cells (APCs).. |
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| DC22393 | IW-927 | A potent TNFα/TNFRc1 interaction antagonist with IC50 of 50 nM, with no affinity for the related cytokine receptors TNFRc2 or CD40, and no cytotoxicity (>100 uM). |
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| DC22618 | MMAD hydrochloride | A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).. |
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| DC11641 | Cridanimod Featured | A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. |
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| DC22607 | Masitinib mesylate | A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays. |
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| DC23995 | Lck inhibitor 2 Featured | A potent tyrosine kinases inhibitor with IC50 of 13/9/3/26/2 nM for Lck/Btk/Lyn/Syk/Txk.. |
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| DC11922 | BC-1382 | A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM. |
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| DC22374 | BMS-299897 | A potent γ-secretase inhibitor that preferentially inhibits cleavage of the APP CTF cleavage with IC50 of 7.1 nM. |
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| DC24011 | (±)-BI-D | A potent, allosteric HIV integrase inhibitor (Kd=34 nM) that binds the LEDGF/p75 binding site on integrase. |
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| DC20541 | RUNX1-IN-17 | A potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays. |
|
| DC11656 | AMPK-Activator-13 | A potent, allosteric, α1-selective small molecule activator of AMPK (EC50=20 nM). |
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| DC23288 | SMBA1 | A potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation. |
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| DC23992 | FAAH inhibitor 1 | A potent, and selective FAAH inhibitor with IC50 of 18 nM. |
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| DC22748 | UBP 302 | A potent, and selective GluR5-subunit containing kainate receptor antagonist with Kd of 402 nM. |
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| DC11643 | Olomoucine Featured | A potent, ATP-competetive CDKs inhibitor with IC50 of 7, 7, 7, 3 uM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk/p35 kinase. |
|
| DC11714 | PV-1019 | A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |
|
| DC20475 | Nek2 inhibitor 72 | A potent, ATP-competitive and relative selective Nek2 inhibitor with IC50 of 0.27 uM. |
|
| DC23063 | FAUC 1104 | A potent, biased allosteric agonist of CXCR3 (pEC50=5.22) that activates solely G proteins, induces chemotaxis, but fails to induce receptor internalization or β-arrestin 2 recruitment.. |
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| DC23064 | FAUC 1036 | A potent, biased allosteric agonist of CXCR3 (pEC50=6.64), selectively induces chemotaxis and receptor internalization, and induces β-arrestin 2 recruitment without any stimulation of G proteins.. |
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| DC11843 | MT-031 | A potent, brain penetrant, dual MAO-A and AChE inhibitor that shows neuroprotective effects both in vitro and in vivo. |
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| DC22801 | MK2 inhibitor III | A potent, cell-permeable inhibitor of MK2 with IC50 of 8.5 nM. |
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| DC20868 | CCG-203586 | A potent, CNS-active Glucosylceramide synthase (GCS) inhibitor with IC50 of 27 nM. |
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| DC22472 | Naltrexone Featured | A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively. |
|
| DC22615 | Rosuvastatin | A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM. |
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| DC20318 | BCML | A potent, competitive inhibitor of quinine-activated bitter taste receptor T2R4 with IC50 of 59 nM.. |
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| DC11767 | IJ-5 | A potent, covalent inhibitor of ubiquitin-conjugating enzyme UbcH5 with Kd of 5.189 uM, 3.578 uM, and 2.577 uM for UbcH5a, UbcH5b, and UbcH5c, respectively. |
|
| DC11624 | WIN-18446 | A potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM. |
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| DC20702 | Ilepatril | A potent, dual ACE-neutral endopeptidase (vasopeptidase) inhibitor with IC50 of 0.053 and 5.0 nM, respectively. |
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