Cat. No. | Product name | CAS No. |
DC6301 |
PLX-4720
Featured
PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
918505-84-7 |
DC10786 |
PLX51107
Featured
PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
1627929-55-8 |
DC21518 |
PLX5622
Featured
PLX5622 is a a potent, selective, orally active inhibitor of CSF1R tyrosine kinase (c-Fms) activity with Ki of 5.9 nM, 60-fold less potency against KIT. |
1303420-67-8 |
DC8107 |
PLX647
Featured
PLX647 is a highly specific dual FMS/KIT kinase inhibitor with IC50 of 28/16 nM respectively. |
873786-09-5 |
DC9814 |
PLX7904(PB04)
Featured
PLX7904(PB04) is a potent and selective paradox-breaker RAF inhibitor. |
1393465-84-3 |
DC22200 |
PMX-53
Featured
PMX53 (Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg)) is a potent C5a receptor (CD88) antagonist with IC50 of 20 nM, also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells; PMX-53 (10 nM) inhibited C5a-induced Ca(2+) mobilization in HMC-1 cells, but at higher concentrations (>30 nM) it caused degranulation in LAD2 mast cells, CD34(+) cell-derived mast cells, and RBL-2H3 cells stably expressing MrgX2; inhibits zymosan-, carrageenan-, LPS- and antigen-induced hypernociception in rats. |
219639-75-5 |
DC7241 |
PND-1186
Featured
PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM. |
1061353-68-1 |
DCAPI1447 |
Pneumocandin B0
Featured
Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, notably Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β |
135575-42-7 |
DC21521 |
PNU-112455A
Featured
PNU-112455A is an ATP-competitive CDK2/5 inhibitor with Ki of 2 uM and 2 uM for cdk2·GST-cyclin E and cdk5·GST-p25 respectively, shows no activity against c-c-Met, IGR-1R, and ERK2.. |
21886-12-4 |
DC7588 |
PNU120596
Featured
PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM. |
501925-31-1 |
DC7648 |
PNU159682
Featured
PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin). |
202350-68-3 |
DC10760 |
Pocapavir
Featured
Pocapavir is an investigational enterovirus (EV) capsid inhibitor. |
146949-21-5 |
DC6504 |
Patchouli Alcohol
Featured
Pogostemon (patchouli) leaves and their extracted oils are used in perfumes and in traditional medicine to relieve sunstroke, stop vomiting, and increase appetite. |
5986-55-0 |
DC26116 |
Poloppin
Featured
Poloppin is a cell-active, small molecule inhibitor of protein-protein interaction via the Polo-box domain (PBD) of the mitotic Polo-like kinase (PLK) with IC50 of 26.9 uM (PLK1) in FP assays. |
683808-78-8 |
DC9594 |
Poloxin
Featured
Poloxin is a non-ATP competitive Polo-like Kinase 1 (PLK1) inhibitor that targets the polo-box domain. |
321688-88-4 |
DC10214 |
Polymyxin B sulphate
Featured
Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. |
1404-26-8 |
DC26126 |
Cereblon Ligand-Linker Conjugates 9(E3 Ligase Ligand-Linker Conjugates 2)
Featured
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. |
1818885-63-0 |
DC9742 |
Ponesimod
Featured
Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
854107-55-4 |
DC10829 |
Porcupine-IN-1
Featured
Porcupine-IN-1 is potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. |
2036044-77-4 |
DCAPI1093 |
Posaconazole
Featured
Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. |
171228-49-2 |
DC11914 |
Poseltinib
Featured
Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM. |
1353552-97-2 |
DC8022 |
R-268712
Featured
Potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~ 5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomeruloscler |
879487-87-3 |