Cat. No. | Product name | CAS No. |
DC10823 |
SAR-20347
Featured
SAR-20347 is an inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50s of 0.6, 23, 26 and 41 nM, respectively. |
1450881-55-6 |
DC10499 |
SAR348830
Featured
SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK). |
1462949-64-9 |
DC22521 |
SAR405
Featured
SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM. |
1523406-39-4 |
DC9854 |
SAR407899
Featured
SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
923359-38-0 |
DC7276 |
Saracatinib (AZD0530)
Featured
Saracatinib (AZD0530) is a potent Src inhibitor with IC50 of 2.7 nM, and potent to c-Yes, Fyn, Lyn, Blk, Fgr and Lck; less active for Abl and EGFR (L858R and L861Q). |
379231-04-6 |
DC12276 |
Saridegib (IPI-926; Patidegib)
Featured
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. |
1037210-93-7 |
DC12047 |
Sarolaner(PF-6450567)
Featured
Sarolaner is a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs |
1398609-39-6 |
DC9313 |
Sarpogrelate (hydrochloride)
Featured
Sarpogrelate(MCI-9042) hydrochloride, a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. |
135159-51-2 |
DC9215 |
Sarsasapogenin(Spirostan-3-ol)
Featured
Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. |
82597-74-8 |
DC9692 |
Volitinib(Savolitinib)
Featured
Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity. |
1313725-88-0 |
DCAPI1568 |
Saxagliptin Hydrochloride
Featured
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. |
709031-78-7 |
DC8875 |
Saxagliptin
Featured
Saxagliptin is a selective and reversible DPP4 inhibitor with IC50 of 26 nM and Ki of 1.3 nM. |
361442-04-8 |
DC2097 |
SB202190
Featured
SB 202190 is a pyridinyl imidazole that inhibits the p38 pathway. |
152121-30-7 |
DC4227 |
SB216763
Featured
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). |
280744-09-4 |
DC7807 |
SB 239063
Featured
SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
193551-21-2 |
DC9459 |
SB 415286
Featured
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. |
264218-23-7 |
DC22223 |
SB02024
Featured
SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro. |
2126737-28-6 |
DC1004 |
SB-203580
Featured
SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM and blocks PKB phosphorylation with IC50 of 3-5 μM. |
152121-47-6 |
DC9924 |
SB218078
Featured
SB218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). |
135897-06-2 |
DC7913 |
SB225002
Featured
SB225002 is a potent, and selective CXCR2 antagonist with IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2, > 150-fold selectivity over the other 7-TMRs tested. |
182498-32-4 |
DC4102 |
SB-269970,SB 269970
Featured
SB269970 is a potent and selective 5-HT7 receptor antagonist. |
201038-74-6 |
DC7495 |
SB-334867 HCl
Featured
SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
249889-64-3 |