| DC8401 |
BI-847325
Featured
|
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. |
|
| DC9888 |
BI-9564
Featured
|
BI-9564 is a selective, and cell-permeable BRD9 BD inhibitor, with Kd of 5.9 nM for BRD9, and IC50 of > 100 μM for BET family. |
|
| DC10404 |
BIA 10-2474
Featured
|
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
|
| DC20788 |
BIBO-3304
Featured
|
BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively. |
|
| DC7085 |
BIBR-1532
Featured
|
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM. |
|
| DCAPI1112 |
BIBR 953(Dabigatran)
Featured
|
BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. |
|
| DC1010 |
BIBR-1048 (Dabigatran etexilate)
Featured
|
BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. |
|
| DC9670 |
BIBS39
Featured
|
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. |
|
| DC1024 |
Afatinib (BIBW2992)
Featured
|
BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
|
| DC10890 |
Bictegravir
Featured
|
Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. |
|
| DC7098 |
BI-D1870
Featured
|
BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC50s are 31 nM, 24 nM, 18 nM, 15 nM, respectively. |
|
| DC7086 |
BIIB021(CNF2024)
Featured
|
BIIB021(CNF2024) is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively. |
|
| DC8263 |
Bikinin
Featured
|
Bikinin is a strong activator of brassinosteroid (BR) signaling. |
|
| DC7995 |
Bilastine
Featured
|
Bilastine is a selective histamine H1 receptor antagonist used for treatment of allergic rhinoconjunctivitis and urticaria. |
|
| DC22281 |
Bilobalide
Featured
|
Bilobalide is a sesquiterpene lactone which is found in extracts of G. biloba. |
|
| DCAPI1079 |
Bimatoprost
Featured
|
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. |
|
| DC6801 |
Bindarit
Featured
|
Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. |
|
| DC7663 |
BIO
Featured
|
BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor. |
|
| DC8368 |
BIO-acetoxime
Featured
|
BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO |
|
| DC7603 |
Bioymifi
Featured
|
Bioymifi(DR5 Activator) is the first novel and potent small-molecule activatior of the TRAIL receptor DR5 in human cancer cells. |
|
| DC23078 |
Biperiden
Featured
|
Biperiden (KL 373) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
|
| DC25079 |
Biperiden hydrochloride
Featured
|
Biperiden Hcl (NSC 170950, NSC 84989) is a centrally-acting antiparkinsonian agent that functions as a selective central M1 cholinoreceptors blocker.. |
|
| DC7836 |
Doramapimod (BIRB-796)
Featured
|
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
|
| DC5023 |
Birinapant (TL32711)
Featured
|
Birinapant (TL32711) is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. |
|
| DC10863 |
Bis(tributylammonium) difluoromethylenediphosphonate
Featured
|
Bis(tributylammonium) difluoromethylenediphosphonate |
|
| DC10434 |
Bisantrene
Featured
|
Bisantrene is a highly effective antitumor drug, targets eukaryotic type II topoisomerases. |
|
| DC10504 |
BISF-3
Featured
|
BISF CAS 118511-97-0 |
|
| DC10052 |
Bisindolylmaleimide X(Ro 31-8425)
Featured
|
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). |
|
| DC8504 |
Bisindolylmaleimide X HCl
Featured
|
Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). |
|
| DC8882 |
Bitopertin
Featured
|
Bitopertin, also known as RG1678, is a potent and selective inhibitor of GlyT1 with an EC50 of 30nM. |
|
