| DC9616 |
BIX 02565
Featured
|
BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.
|
|
| DC7374 |
BIX01294
Featured
|
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM. |
|
| DC5002 |
BIX02188 (BIX 02188）
Featured
|
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
|
| DC22637 |
BKI1369
Featured
|
BKI-1369 is a bumped kinase inhibitor (BKI). BKI-1369 increases human Ether-a-go-go-related gene (hERG)-inhibitory activity with an IC50 of 1.52 μM. BKI-1369 reduces the parasite burden and diseases severity in the gnotobiotic pig model. BKI-1369 has been well characterized for potency, stability, metabolism, toxicity, pharmacokinetics and is potent against C. parvum in infected mice and calves. |
|
| DC5154 |
BKM120 (NVP-BKM120, Buparlisib)
Featured
|
BKM120 is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. |
|
| DC20800 |
BL-918
Featured
|
BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells. |
|
| DC12391 |
BL-AD008
Featured
|
BL-AD008 (BL-AD 008) is a novel small molecule, dual-target activator targeting AMPK/ZIPK; demonstrates remarkable anti-proliferative activities toward cervical cancer cells and could induce apoptosis by death-receptor and mitochondrial pathways; also sho |
|
| DC4196 |
Bleomycin Sulfate
Featured
|
Bleomycin sulfate (Blenoxane) is a glycopeptide antibiotic and an anticancer agent for squamous cell carcinomas (SCC) with IC50 of 4 nM in UT-SCC-19A cells. |
|
| DC20801 |
BLT-1
Featured
|
BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages. |
|
| DC10530 |
BLU-285 (Avapritinib)
Featured
|
BLU-285 is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0.27 nM for KIT D816V. |
|
| DC10092 |
BLU554(Fisogatinib)
Featured
|
BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor. |
|
| DC11479 |
BLU-667 (Pralsetinib)
Featured
|
BLU-667 (Pralsetinib) is a highly potent, selective, next generation RET inhibitor with IC50 of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. |
|
| DC11152 |
BLU-782
Featured
|
BLU-782 (BLU782) is a novel potent, selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 Nm. |
|
| DC8280 |
BLU-9931
Featured
|
BLU9931 is the first selective small molecule inhibitor of FGFR4 with IC50 of 3 nM; less potent for FGFR1/2/3(IC50> 150 nM). |
|
| DC8103 |
BLZ-945
Featured
|
BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases. |
|
| DC9853 |
BM212
Featured
|
BM-212 is a potent antimycobacterial agent and MmpL3 inhibitor. |
|
| DC7959 |
BMH-21
Featured
|
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX. |
|
| DC7840 |
BML-190
Featured
|
BML-190 is an indomethacin morpholinylamide which functions as a selective inverse agonist of the human cannabinoid CB2 receptor. |
|
| DC8660 |
BML-210(CAY10433)
Featured
|
BML-210 is the novel HDAC inhibitor, and its mechanism of action has not been characterized. |
|
| DC8270 |
BML-277
Featured
|
BML-277 (C 3742) is a selective Chk2 (checkpoint kinase 2) inhibitor with an IC50 of 15 nM. |
|
| DC9951 |
AMBMP
Featured
|
AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer c |
|
| DC8453 |
Talazoparib（BMN-673）tosylate
Featured
|
Talazoparib, also known as BMN-673 and MDV-3800, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity (PARP1 IC50 = 0.57 nmol/L). Talazoparib acts as an inhibitor of poly ADP ribose polymerase(PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors because of an accumulation of DNA damage. Talazoparib is theorized to have a higher potency than olaparib due to the additional mechanism of action called PARP trapping. PARP trapping is the mechanism of action where the PARP molecule is trapped on the DNA, which interferes with the cells ability to replicate. Talazoparib is found to be ~100 fold more efficient in PARP trapping than olaparib. |
|
| DC2008 |
Talazoparib(BMN-673)
Featured
|
BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. |
|
| DC23833 |
SB 4 (Eticovo)
Featured
|
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM, enhances the efficacy of BMPs and activates endogenous BMP4 target genes. |
|
| DC22988 |
BMS-189453
Featured
|
BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ. |
|
| DC8513 |
BMS-3
Featured
|
BMS-3 is a potent inhibitor of the LIM kinase. It has IC50's of 5nM and 6 nM for LIMK1 and LIMK2 respectively. |
|
| DC7375 |
BMS-303141
Featured
|
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor with IC50 value of 0.13 uM (human recombinant ACL). |
|
| DC8457 |
BMS-309403
Featured
|
BMS309403 is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E. |
|
| DC5037 |
BMS-536924
Featured
|
BMS-536924 is an ATP-competitive IGF-1R inhibitor with IC50 of 100 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. |
|
| DC7897 |
BMS-582949 HCl
Featured
|
BMS-582949 is a dual action p38 Kinase Inhibitor. |
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