| DC8440 |
Erythromycin Cyclocarbonate
Featured
|
Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome. |
|
| DC20244 |
ES9-17
Featured
|
ES9-17 is a novel CME inhibitor. |
|
| DC4171 |
Escitalopram oxalate
Featured
|
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
|
| DC21000 |
ESI-05
Featured
|
ESI-05 is a potent EAPC2-specific antagonist that inhibits cAMP-mediated EPAC2 GEF activity with apparent IC50 of 0.43 uM. |
|
| DC8443 |
ESI-09
Featured
|
ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. |
|
| DC10714 |
Esonarimod (KE-298)
Featured
|
Esonarimod (KE-298) is a new antirheumatic drug. |
|
| DC23056 |
esperamicin A1
Featured
|
Esperamicin A1 is an enediyne antitumor antibiotics of bacterial origin. |
|
| DC9440 |
Estropipate
Featured
|
Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis. |
|
| DC8182 |
Bempedoic Acid(ETC-1002;ESP-55016)
Featured
|
ETC-1002(ESP-55016) is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM). |
|
| DC8489 |
ETC-159
Featured
|
ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits _beta_-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM. |
|
| DC21003 |
ETC-206
Featured
|
ETC-206 (ETC-1907206) is a novel potent, selective MNK1/2 inhibitor with IC50 of 64/86 nM, inhibits eIF4E phosphorylation inhibition in HeLa cell line with IC50 of 321 nM. |
|
| DC8123 |
ETH 157（Sodium ionophore II）
Featured
|
ETH 157（Sodium ionophore II）is a neutral ionophore for liquid-membrane electrodes of high selectivity for Na+. |
|
| DC8821 |
Etifoxine Hydrochloride
Featured
|
Etifoxine Hydrochloride is a psychotropic agent with anxiolytic and anticonvulsant activity. Etifoxine Hydrochloride is an activator of GABAA R β2 and GABAA R β3. |
|
| DC10046 |
Etizolam
Featured
|
Etizolam(AHR3219; Y7131) is a benzodiazepine analog. |
|
| DC7411 |
Etofenamate
Featured
|
Etofenamate is a non-steroidal anti-inflammatory drug used for the treatment joint and muscular pain. |
|
| DC10239 |
Etoricoxib
Featured
|
Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties. |
|
| DC10103 |
ETP-46321
Featured
|
ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R). |
|
| DC7124 |
ETP-46464
Featured
|
ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively). |
|
| DC10040 |
Etrasimod(APD334)
Featured
|
Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1(S1P1) receptor with an IC50 value of 1.88 nM in CHO cells. |
|
| DC8870 |
Eupatilin
Featured
|
Eupatilin is a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells. |
|
| DC7125 |
Evacetrapib (LY2484595)
Featured
|
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure. |
|
| DC9685 |
Evatanepag (CP-533536)
Featured
|
Evatanepag (CP-533536) is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM. |
|
| DC1501 |
Everolimus
Featured
|
Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
|
| DC10380 |
Evobrutinib
Featured
|
Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174. |
|
| DC7126 |
QNZ(EVP4593)
Featured
|
EVP4593 is a derivative of 6-aminoquinazoline class that has been previously isolated as an inhibitor of PMA/PHA-induced NF-κB pathway activation in Jurkat cells (IC50= 9 nM). |
|
| DC7987 |
Encenicline hydrochloride (EVP-6124)
Featured
|
Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
|
| DC8342 |
EW-7197
Featured
|
EW-7197 is a potent ALK5 inhibitor. EW-7197 showed potent in vivo anti-metastatic activity, indicating its potential for use as an anti-cancer therapy. |
|
| DC11634 |
EX-229
Featured
|
EX229 is a small molecule AMPK activator that dose-dependently increases AMPK activity of α1-, α2-, β1- and β2-containing complexes at 50 uM |
|
| DC7578 |
Exatecan (Mesylate)
Featured
|
Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. |
|
| DC8260 |
Exemestane(FCE 24304)
Featured
|
Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively. |
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