| DC8085 |
Fexaramine
Featured
|
Fexaramine is a potent, selective FXR activator. |
|
| DC8070 |
Fexarene
Featured
|
Fexarene is a potent, selective farnesoid X receptor agonist. |
|
| DC8071 |
Fexarine
Featured
|
Fexarine is a potent, selective farnesoid X receptor agonist. |
|
| DC7811 |
Fexinidazole
Featured
|
Fexinidazole is a new Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness |
|
| DC9175 |
Fexofenadine Hydrochloride
Featured
|
Fexofenadine is a third-generation antihistamine pharmaceutical drug used in the treatment of allergy symptoms, such as hay fever, nasal congestion, and urticaria. |
|
| DC8195 |
FG2216
Featured
|
FG-2216 is a potent HIF-prolyl hydroxylase inhibitor with IC50 of 3.9 uM for PDH2 enzyme; orally bioavailable and induced significant and reversible Epo induction in vivo. |
|
| DC5193 |
Roxadustat(FG-4592)
Featured
|
FG-4592 is an HIF αprolyl hydroxylase inhibitor, stabilizes HIF-2 and induces EPO production. |
|
| DC10128 |
FGF401( Roblitinib)
Featured
|
FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. |
|
| DC7637 |
FH1(BRD-K4477)
Featured
|
FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes. |
|
| DC7414 |
FH535
Featured
|
FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
|
| DC20385 |
FICZ
Featured
|
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM. |
|
| DC1057 |
Fidaxomicin (Dificid)
Featured
|
Fidaxomicin, is an antibiotic that belongs to the class of macrocylic antibiotics. |
|
| DC8330 |
FIIN-2
Featured
|
FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. |
|
| DC9642 |
FIIN-3
Featured
|
FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. |
|
| DC9349 |
Fimasartan
Featured
|
Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure.
|
|
| DC10522 |
FIN56
Featured
|
FIN56 is a specific inducer of ferroptosis. |
|
| DC8847 |
Finafloxacin (BAY35-3377)
Featured
|
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. |
|
| DC12637 |
Finerenone
Featured
|
Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease. |
|
| DC8200 |
Firategrast(SB-683699)
Featured
|
Firategrast is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). |
|
| DC21015 |
FIT-039
Featured
|
FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM). |
|
| DC9845 |
FITM
Featured
|
FITM is a nove mGlu1 inhibitor. FITM shows high affinity (Ki = 2.5 nM, fig. S2) and selectivity for mGlu1 over mGlu5. |
|
| DC20386 |
Pioglitazone
Featured
|
Pioglitazone is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. |
|
| DC7112 |
FK 3311
Featured
|
FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent. |
|
| DC10845 |
FL-411
Featured
|
FL-411 is a selective BRD4 inhibitor. |
|
| DC2014 |
Flavopiridol
Featured
|
Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM, and CDK7 with IC50 of 300 nM. |
|
| DC8780 |
Flavopiridol Hydrochloride
Featured
|
Flavopiridol hydrochloride competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. |
|
| DC11414 |
Flavoxate Hydrochloride
Featured
|
Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic. |
|
| DC9623 |
Flecainide (acetate)
Featured
|
Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
|
|
| DC7415 |
FLI-06
Featured
|
FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM). |
|
| DC9321 |
Flibanserin
Featured
|
Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.
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