| DC9154 |
Cetirizine 2HCl |
Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. |
|
| DC9582 |
Cilomilast |
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
|
| DC11154 |
CR6086 |
CR6086 (CR-6086) is a potent, selective prostaglandin E2 receptor 4 (EP4) antagonist with Ki of 16.6 nM (hEP4 receptor), inhibits PGE2-stimulated cAMP production with IC50 of 22 nM. |
|
| DC8997 |
Cromolyn sodium |
Cromolyn sodium is an antiallergic drug. |
|
| DC9689 |
Danirixin (GSK1325756)
Featured
|
Danirixin(GSK1325756) is a selective CXCR2 antagonist. |
|
| DC8171 |
Decernotinib (VX-509,adelatinib)
Featured
|
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays. |
|
| DC11890 |
Delgocitinib
Featured
|
Delgocitinib (JTE-052, LEO 124249) is a potent, selective, orally active, pan-JAK inhibitor with IC50 of 2.8, 2.6, 13 and 58 nM for JAK1,2,3 and Tyk2, respectively. |
|
| DC10141 |
E6005
Featured
|
E6005 potently and selectively inhibited human PDE4 activity with an IC50 of 2.8 nM and suppressed the production of various cytokines from human lymphocytes and monocytes with IC50 values ranging from 0.49 to 3.1 nM. |
|
| DC11398 |
Edicotinib（JNJ-40346527）
Featured
|
Edicotinib（JNJ-40346527）is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. |
|
| DC10380 |
Evobrutinib
Featured
|
Evobrutinib is an inhibitor of Bruton's tyrosin kinase (Btk) inhibitor extracted from patent US20140162983 example 0174. |
|
| DC11278 |
Fevipiprant
Featured
|
Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1.1nM at the CRTh2 receptor and an IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change. |
|
| DC8936 |
Fingolimod |
Fingolimod(FTY720 free base) is a S1P antagonist with IC50 of 0.033 nM. |
|
| DC3154 |
Fingolimod HCl（FTY-720）
Featured
|
FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM. |
|
| DC9942 |
GDC-0853(RG7845)
Featured
|
GDC-0853 is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. |
|
| DC10721 |
Gefapixant(AF-219,MK-7264)
Featured
|
Gefapixant(AF-219,MK-7264) is novel P2X3 receptor antagonist. |
|
| DC12342 |
Gemilukast (ONO-6950) |
Gemilukast is an orally active and potent dual cysteinyl leukotriene 1 and 2 receptors (CysLT1 and CysLT2) antagonist, with IC50s of 1.7, 25 nM for human CysLT1 and CysLT2, respectively. |
|
| DC8779 |
Glycopyrrolate
Featured
|
Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
|
| DC7137 |
Filgotinib(GLPG0634)
Featured
|
Filgotinib (GLPG0634) is a selective, orally available JAK1 inhibitor with anti-inflammatory and antiviral activities. Filgotinib can effectively inhibit the activities of JAK1, JAK2, JAK3 and TYK2 with IC50 values of 10 nM, 28 nM, 810 nM and 116 nM, respectively. Filgotinib also inhibits HIV-1 driven gene transcription and reduces proliferation of HIV-1 infected cells. Filgotinib can be used in the study of rheumatoid arthritis and inflammatory bowel disease. |
|
| DC9943 |
PI3Kδ inhibitor GS2269557 |
GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms. |
|
| DC9944 |
PI3Kδ inhibitor GS2292767 |
GSK2292767 is a potent and selective PI3Kδ inhibitor. |
|
| DC8767 |
GSK256066
Featured
|
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. |
|
| DC9713 |
GSK2981278
Featured
|
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). |
|
| DC10787 |
GSK2982772
Featured
|
GSK2982772 is a potent and ATP competitive RIP1 inhibitor with an IC50 of 16 nM. |
|
| DC9715 |
CHR5154
Featured
|
GSK3117391 (CHR5154) is a HDAC inhibitor. |
|
| DC7837 |
GW-3965 hydrochloride
Featured
|
GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. |
|
| DC8872 |
Iguratimod
Featured
|
Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. |
|
| DC9389 |
INCB3344 |
INCB3344 is a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor; inhibits the binding of CCL2 to mouse monocytes with nanomolar potency (IC50 = 10 nM).
|
|
| DC2071 |
ABR-215062 (Laquinimod)
Featured
|
Laquinimod (ABR-215062) is a potent immunomodulator. |
|
| DCAPI1208 |
L-NAME HCl |
L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. |
|
| DC9104 |
Loratadine |
Loratadine(SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
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