Cat. No. | Product name | CAS No. |
DC5061 |
GYKI 52466 dihydrochloride
GYKI 52466 dihydrochloride is a selective non-competitive AMPA receptor antagonist (IC50 values are 10-20, ~ 450 and >> 50 μM for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. |
102771-26-6 |
DC11416 |
HC-067047
Featured
HC-067047 is a potent and selective TRPV4 antagonist with IC50 values of 48 ± 6 nM, 133 ± 25 nM, and 17 ± 3 nM, respectively in human, rat, and mouse. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). |
883031-03-6 |
DC11118 |
HZ-166
HZ-166 (HZ166) is a GABAA receptor subtype-selective benzodiazepine site ligand with preferential activity at α2- and α3-GABA(A) receptors. |
612527-56-7 |
DC8601 |
IAA-94
IAA-94 is an indanyloxyacetic acid blocker of epithelial chloride channels. |
54197-31-8 |
DC10078 |
ICA 069673
Featured
ICA 069673 is a potassium channel opener with selective action for KCNQ2 and KCNQ3 (EC50=0.69 μM). No meeasurable activity was displayed over a variety of cardiac ion channels. |
582323-16-8 |
DC8213 |
ICA-121431
Featured
ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. |
313254-51-2 |
DC7213 |
ICILIN
Featured
Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel. |
36945-98-9 |
DC8769 |
IEM 1754 DihydrobroMide
IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
162831-31-4 |
DC11031 |
IK1 inhibitor PA-6
IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM. |
500715-03-7 |
DC10205 |
Ilaprazole
Featured
Ilaprazole (IY-81149) is a proton pump inhibitor; inhibits H+/K+-ATPase with an IC50 of 6.0 μM. |
172152-36-2 |
DC4137 |
Indiplon
Featured
Indiplon is a novel sedative-hypnotic recently approved for the treatment of insomnia. |
325715-02-4 |
DCAPI1506 |
Mitiglinide Calcium
Inhibitor of ATP-sensitive K+ channel activity in MIN 6 cells. Has also been shown to bind sulfonylurea receptors as well. |
145525-41-3 |
DC8124 |
ETH 2120(Sodium ionophore III)
Featured
Ionophore suitable for the assay of sodium activity in blood, plasma, serum. etc. with a solvent polymeric membrane electrode. |
81686-22-8 |
DC7172 |
IOWH-032
iOWH032 is a novel and potent CFTR inhibitor (IC50=1.01 uM) in T84 and CHO-CFTR cell based assays. |
1191252-49-9 |
DCAPI1573 |
Ipragliflozin (ASP1941)
Featured
Ipragliflozin (ASP1941) is a Novel Selective Sodium-Dependent Glucose Co-Transporter 2 Inhibitor, on Urinary Glucose Excretion in Healthy Subjects |
761423-87-4 |
DC4128 |
Ivacaftor (VX-770)
Featured
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. |
873054-44-5 |
DC12271 |
JNJ-54175446
Featured
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
1627902-21-9 |
DC11229 |
JNJ-55511118
JNJ-55511118 (JNJ55511118) is a selective, orally available AMPA receptor containing TARP-γ8 negative modulator with Ki of 26 nM, displays no significant activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. |
2036081-86-2 |
DC9276 |
KM 11060
Featured
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity. |
774549-97-2 |
DC8788 |
Ko 143
Featured
Ko 143 is a potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM), Ko 143 displays > 200-fold selectivity over P-gp and MRP-1 transporters. |
461054-93-3 |
DC7067 |
KPT-330(Selinexor)
Featured
KPT-330, analog of KPT-185, is an orally bioavailable selective CRM1 inhibitor. |
1393477-72-9 |
DC9256 |
KS176
Featured
KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. |
1253452-78-6 |